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10.1186/s13041-017-0292-0 http://scihub22266oqcxt.onion/10.1186/s13041-017-0292-0 C5399341!5399341 !28427452     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28427452 &cmd=llinks): Failed to open stream: HTTP request failed! 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Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia |pdf=|usr=}}{{28427452 }} gab.com Text Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia JO: Mol Brain http://www.kidney.de/pget.php?&tw=1&pmid=28427452 #FOAvip Autism spectrum disorder (ASD) is a range of neurodevelopmental conditions that are sharply increasing in prevalence worldwide. Intriguingly, ASD is often accompanied by an array of systemic aberrations including (1) increased serotonin, (2) various modes of gastrointestinal disorders, and (3) inflammatory bowel disease (IBD), albeit the underlying cause for such comorbidities remains uncertain. Also, accumulating number of studies report that the gut microbial composition is significantly altered in children with ASD or patients with IBD. Surprisingly, when we analyzed the gut microbiota of poly I:C and VPA-induced mouse models of ASD, we found a distinct pattern of microbial dysbiosis that highly recapitulated those reported in clinical cases of ASD and IBD. Moreover, we report that such microbial dysbiosis led to notable perturbations in microbial metabolic pathways that are known to negatively affect the host, especially with regards to the pathogenesis of ASD and IBD. Lastly, we found that serum level of serotonin is significantly increased in both poly I:C and VPA mice, and that it correlates with increases of a bacterial genus and a metabolic pathway that are implicated in stimulation of host serotonin production. Our results using animal model identify prenatal environmental risk factors of autism as possible causative agents of IBD-related gut microbial dysbiosis in ASD, and suggest a multifaceted role of gut microbiota in the systemic pathogenesis of ASD and hyperserotonemia. Twit Text FOAVip Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia ????Mol Brain http://www.kidney.de/pget.php?&tw=1&pmid=28427452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28427452 #FOAvip English Wikipedia <ref>{{Cite pmid|28427452 }}</ref> Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia #MMPMID28427452 Lim JS ; Lim MY ; Choi Y ; Ko G Mol Brain 2017[Apr]; 10 (1 ): 14 PMID28427452 show ga Autism spectrum disorder (ASD) is a range of neurodevelopmental conditions that are sharply increasing in prevalence worldwide. Intriguingly, ASD is often accompanied by an array of systemic aberrations including (1) increased serotonin, (2) various modes of gastrointestinal disorders, and (3) inflammatory bowel disease (IBD), albeit the underlying cause for such comorbidities remains uncertain. Also, accumulating number of studies report that the gut microbial composition is significantly altered in children with ASD or patients with IBD. Surprisingly, when we analyzed the gut microbiota of poly I:C and VPA-induced mouse models of ASD, we found a distinct pattern of microbial dysbiosis that highly recapitulated those reported in clinical cases of ASD and IBD. Moreover, we report that such microbial dysbiosis led to notable perturbations in microbial metabolic pathways that are known to negatively affect the host, especially with regards to the pathogenesis of ASD and IBD. Lastly, we found that serum level of serotonin is significantly increased in both poly I:C and VPA mice, and that it correlates with increases of a bacterial genus and a metabolic pathway that are implicated in stimulation of host serotonin production. Our results using animal model identify prenatal environmental risk factors of autism as possible causative agents of IBD-related gut microbial dysbiosis in ASD, and suggest a multifaceted role of gut microbiota in the systemic pathogenesis of ASD and hyperserotonemia. |*Environment [MESH] |*Gastrointestinal Microbiome [MESH] |*Models, Biological [MESH] |Animals [MESH] |Autistic Disorder/blood/*complications/*microbiology [MESH] |Bacteria/classification [MESH] |Biodiversity [MESH] |Diet [MESH] |Dysbiosis/blood/*complications/microbiology [MESH] |Inflammatory Bowel Diseases/blood/*complications/microbiology [MESH] |Metabolic Networks and Pathways/drug effects [MESH] |Mice, Inbred C57BL [MESH] |Poly I-C/pharmacology [MESH] |Risk Factors [MESH] |Serotonin/*blood [MESH]Modeling environmental risk factors of autism in mice induces IBD-rela(epmc).pdf DeepDyve Pubget Overpricing