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Accuracy of glomerular filtration rate equations for chronic kidney disease
patients at the G3a stage: a single-center cross-sectional study
#MMPMID28235417
Dou Y
; Sun X
; Liu D
; Zhang L
; Xiao J
; Cheng G
; Yu D
; Zhao Z
BMC Res Notes
2017[Feb]; 10
(1
): 107
PMID28235417
show ga
BACKGROUND: Kidney disease improving global outcomes provided a new
classification for chronic kidney disease (CKD) by subdividing the G3 stage into
G3a and G3b stages based on glomerular filtration rate (GFR) in 2012. Currently,
a few methods are used to evaluate GFR, including measured GFR (mGFR) and
estimated GFR (eGFR). One of the mGFR was (99m)Tc-DTPA scintigraphy method and
eGFR using GFR equations were used clinically. Equations were modification of
diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration
(CKD-EPI), and Chinese adapted MDRD (C-MDRD). This study assessed the accuracy of
three different equations for estimated glomerular filtration rate (eGFR) with
mGFR using DTPA scintigraphy method as the standard in a population of Chinese
chronic kidney disease patients at the G3a stage. RESULTS: One hundred and
twenty-two patients (age 52.0 ± 15.6 years, 69 were male) were determined as CKD
stage 3 based on mGFR. Patients were divided into G3a (47 patients) and G3b (75
patients) subgroups. Bias between eGFR for CKD-EPI and reference mGFR was
0.92 mL/min and 95% limits of agreement was -38.82 to 40.67 mL/min. Bias between
eGFR for C-MDRD and mGFR was 3.76 and 95% limits of agreement was -39.32 to
46.85 mL/min. Bias between eGFR for MDRD and mGFR was 3.53 and 95% limits of
agreement was -43.35 to 50.4 mL/min. The CKD-EPI equation showed better
diagnostic value with a greater area under the receiver operating characteristic
curve (AUC: 0.763). AUC for MDRD and C-MDRD were 0.75 and 0.757, respectively.
CONCLUSIONS: There were no obvious advantages in accuracy, sensitivity, and
specificity for the diagnosis of patients at the G3a stage using the CKD-EPI
equation.
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