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10.1038/cdd.2016.25 http://scihub22266oqcxt.onion/10.1038/cdd.2016.25 C5399169!5399169!26967968     free     free     free       Cell+Death+Differ 2016 ; 23 (7): 1099-109 Nephropedia Template TP {{tp|p=26967968|t=2016. Emerging roles for lipids in non-apoptotic cell death |pdf=|usr=}}{{26967968}} gab.com Text Emerging roles for lipids in non-apoptotic cell death JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26967968 #FOAvip Non-apoptotic regulated cell death (RCD) is essential to maintain organismal homeostasis and may be aberrantly activated during certain pathological states. Lipids are emerging as key components of several non-apoptotic RCD pathways. For example, a direct interaction between membrane phospholipids and the pore-forming protein mixed lineage kinase domain-like (MLKL) is needed for the execution of necroptosis, while the oxidative destruction of membrane polyunsaturated fatty acids (PUFAs), following the inactivation of glutathione peroxidase 4 (GPX4), is a requisite gateway to ferroptosis. Here, we review the roles of lipids in the initiation and execution of these and other forms of non-apoptotic cell death. We also consider new technologies that are allowing for the roles of lipids and lipid metabolism in RCD to be probed in increasingly sophisticated ways. In certain cases, this new knowledge may enable the development of therapies that target lipids and lipid metabolic processes to enhance or suppress specific non-apoptotic RCD pathways. Twit Text FOAVip Emerging roles for lipids in non-apoptotic cell death ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26967968 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26967968 #FOAvip English Wikipedia <ref>{{Cite pmid|26967968}}</ref> Emerging roles for lipids in non-apoptotic cell death #MMPMID26967968 Magtanong L; Ko PJ; Dixon SJ Cell Death Differ 2016[Jul]; 23 (7): 1099-109 PMID26967968show ga Non-apoptotic regulated cell death (RCD) is essential to maintain organismal homeostasis and may be aberrantly activated during certain pathological states. Lipids are emerging as key components of several non-apoptotic RCD pathways. For example, a direct interaction between membrane phospholipids and the pore-forming protein mixed lineage kinase domain-like (MLKL) is needed for the execution of necroptosis, while the oxidative destruction of membrane polyunsaturated fatty acids (PUFAs), following the inactivation of glutathione peroxidase 4 (GPX4), is a requisite gateway to ferroptosis. Here, we review the roles of lipids in the initiation and execution of these and other forms of non-apoptotic cell death. We also consider new technologies that are allowing for the roles of lipids and lipid metabolism in RCD to be probed in increasingly sophisticated ways. In certain cases, this new knowledge may enable the development of therapies that target lipids and lipid metabolic processes to enhance or suppress specific non-apoptotic RCD pathways. äEmerging roles for lipids in non-apoptotic cell death (epmc).pdf DeepDyve Pubget Overpricing