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10.1074/jbc.R116.771915 http://scihub22266oqcxt.onion/10.1074/jbc.R116.771915 C5399099!5399099!28264931     free     free     free       J+Biol+Chem 2017 ; 292 (16): 6452-60 Nephropedia Template TP {{tp|p=28264931|t=2017. Key proteins and pathways that regulate lifespan |pdf=|usr=}}{{28264931}} gab.com Text Key proteins and pathways that regulate lifespan JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28264931 #FOAvip Here, we review three sets of key proteins and their corresponding downstream pathways that have been linked to extending lifespan and promoting health span in a wide range of organisms. In particular, we review the biology of the sirtuin family of proteins, the insulin/insulin-like growth factor (IGF) signaling (IIS) pathway, and the mechanistic target of rapamycin (mTOR). Using insights derived from simple model organisms, mice, and humans we discuss how these proteins and pathways may potentially alter the rate of aging. We further describe how knowledge of these pathways may lead to the rational design of small molecules that modulate aging and hence alter the propensity for a host of age-related diseases. Twit Text FOAVip Key proteins and pathways that regulate lifespan ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28264931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28264931 #FOAvip English Wikipedia <ref>{{Cite pmid|28264931}}</ref> Key proteins and pathways that regulate lifespan #MMPMID28264931 Pan H; Finkel T J Biol Chem 2017[Apr]; 292 (16): 6452-60 PMID28264931show ga Here, we review three sets of key proteins and their corresponding downstream pathways that have been linked to extending lifespan and promoting health span in a wide range of organisms. In particular, we review the biology of the sirtuin family of proteins, the insulin/insulin-like growth factor (IGF) signaling (IIS) pathway, and the mechanistic target of rapamycin (mTOR). Using insights derived from simple model organisms, mice, and humans we discuss how these proteins and pathways may potentially alter the rate of aging. We further describe how knowledge of these pathways may lead to the rational design of small molecules that modulate aging and hence alter the propensity for a host of age-related diseases. äKey proteins and pathways that regulate lifespan (epmc).pdf DeepDyve Pubget Overpricing