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10.3389/fimmu.2017.00405 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00405 C5399081!5399081!28484449     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28484449|t=2017. Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update |pdf=|usr=}}{{28484449}} gab.com Text Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28484449 #FOAvip Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease. Twit Text FOAVip Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28484449 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28484449 #FOAvip English Wikipedia <ref>{{Cite pmid|28484449}}</ref> Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update #MMPMID28484449 Su H; Lei CT; Zhang C Front Immunol 2017[]; 8 (ä): ä PMID28484449show ga Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease. äInterleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Upd(epmc).pdf DeepDyve Pubget Overpricing