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10.1038/ncb3496 http://scihub22266oqcxt.onion/10.1038/ncb3496 C5398908!5398908!28346439     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2017 ; 19 (4): 362-74 Nephropedia Template TP {{tp|p=28346439|t=2017. Hippo signaling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade |pdf=|usr=}}{{28346439}} gab.com Text Hippo signaling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28346439 #FOAvip The Hippo pathway senses cellular conditions and regulates YAP/TAZ to control cellular and tissue homeostasis, while TBK1 is central for cytosolic nucleic acid sensing and antiviral defense. The correlation between cellular nutrient/physical status and host antiviral defense is interesting but not well understood. Here we find that YAP/TAZ act as natural inhibitors of TBK1 and are vital for antiviral physiology. Independent of transcriptional regulation and through transactivation domain, YAP/TAZ associate directly with TBK1 and abolish virus-induced TBK1 activation, by preventing TBK1 K63-linked ubiquitination and adaptors/substrates binding. Accordingly, YAP/TAZ deletion/depletion or cellular conditions inactivating YAP/TAZ through Lats1/2 kinases relieve TBK1 suppression and boost antiviral responses, whereas expression of the transcriptionally inactive YAP dampens cytosolic RNA/DNA sensing and weakens the antiviral defense in cells and zebrafish. Thus, we describe a function of YAP/TAZ and the Hippo pathway in innate immunity, by linking cellular nutrient/physical status to antiviral host defense. Twit Text FOAVip Hippo signaling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28346439 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28346439 #FOAvip English Wikipedia <ref>{{Cite pmid|28346439}}</ref> Hippo signaling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade #MMPMID28346439 Zhang Q; Meng F; Chen S; Plouffe SW; Wu S; Liu S; Li X; Zhou R; Wang J; Zhao B; Liu J; Qin J; Zou J; Feng XH; Guan KL; Xu P Nat Cell Biol 2017[Apr]; 19 (4): 362-74 PMID28346439show ga The Hippo pathway senses cellular conditions and regulates YAP/TAZ to control cellular and tissue homeostasis, while TBK1 is central for cytosolic nucleic acid sensing and antiviral defense. The correlation between cellular nutrient/physical status and host antiviral defense is interesting but not well understood. Here we find that YAP/TAZ act as natural inhibitors of TBK1 and are vital for antiviral physiology. Independent of transcriptional regulation and through transactivation domain, YAP/TAZ associate directly with TBK1 and abolish virus-induced TBK1 activation, by preventing TBK1 K63-linked ubiquitination and adaptors/substrates binding. Accordingly, YAP/TAZ deletion/depletion or cellular conditions inactivating YAP/TAZ through Lats1/2 kinases relieve TBK1 suppression and boost antiviral responses, whereas expression of the transcriptionally inactive YAP dampens cytosolic RNA/DNA sensing and weakens the antiviral defense in cells and zebrafish. Thus, we describe a function of YAP/TAZ and the Hippo pathway in innate immunity, by linking cellular nutrient/physical status to antiviral host defense. äHippo signaling governs cytosolic nucleic acid sensing through YAP/TAZ(epmc).pdf DeepDyve Pubget Overpricing