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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2017 ; 12
(4
): e0175461
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Peste des petits ruminants (PPR): A neglected tropical disease in Maghreb region
of North Africa and its threat to Europe
#MMPMID28426782
Baazizi R
; Mahapatra M
; Clarke BD
; Ait-Oudhia K
; Khelef D
; Parida S
PLoS One
2017[]; 12
(4
): e0175461
PMID28426782
show ga
BACKGROUND: Peste des petits ruminants (PPR) is a contagious disease listed by
the World Organisation for Animal health (OIE) as being a specific hazard. It
affects sheep, goats, and wild ungulates, and is prevalent throughout the
developing world particularly Asia, the Middle East, and Africa. PPR has been
targeted for eradication by 2030 by the Food and Agriculture Organization of the
United Nations (FAO) and the OIE, after the successful eradication of the related
disease, rinderpest in cattle. PPR was first reported in 1942 in the Ivory Coast
in Western Africa and has since extended its range in Asia, the Middle East, and
Africa posing an immediate threat of incursion into Europe, South East Asia and
South Africa. Although robust vaccines are available, the use of these vaccines
in a systematic and rational manner is not widespread, resulting in this
devastating disease becoming an important neglected tropical disease in the
developing world. METHODOLOGY: We isolated and characterized the PPR virus from
an outbreak in Cheraga, northern Algeria, during October 2015 by analyzing the
partial N-gene sequence in comparison with other viruses from the Maghreb region.
As well as sequencing the full length viral genome and performing real-time
RT-PCR on clinical samples. Maximum-likelihood and Bayesian temporal and
phylogeographic analyses were performed to assess the persistence and spread of
PPRV circulation from Eastern Africa in the Maghreb region of North Africa.
CONCLUSIONS: Recent PPR outbreaks in Cheraga, in the northern part of Algiers
(October 2015) and North-West Morocco (June, 2015) highlight that PPRV has spread
to the northern border of North Africa and may pose a threat of introduction to
Europe. Phylogeographic analysis suggests that lineage IV PPRV has spread from
Eastern Africa, most likely from the Sudan 2000 outbreak, into Northern Africa
resulting in the 2008 Moroccan outbreak. Maximum-likelihood and Bayesian analysis
shows that these North African viruses cluster closely together suggesting the
existence of continual regional circulation. Considering the same virus is
circulating in Algeria, Morocco and Tunisia, implementation of a common Maghreb
PPR eradication strategy would be beneficial for the region.