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2015 ; 12
(1-2
): 213-9
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Simplified Diagnosis of Cardiovascular Autonomic Neuropathy in Type 2 Diabetes
Using Ewing s Battery
#MMPMID26676669
Pafili K
; Trypsianis G
; Papazoglou D
; Maltezos E
; Papanas N
Rev Diabet Stud
2015[Spr]; 12
(1-2
): 213-9
PMID26676669
show ga
AIM: To find a potential simplification of the established Ewing's battery for
the diagnosis of cardiovascular autonomic neuropathy (CAN) in type 2 diabetes
(T2D). METHODS: We included 152 patients (92 men) with mean age 64.51 ± 7.85
years and median diabetes duration of 12 years. Ewing's battery was used as the
gold standard for the diagnosis of CAN. Against this, we compared the results
from each test and their combinations. RESULTS: The 30:15 ratio exhibited the
best diagnostic performance (AUC = 0.817, 95% CI: 0.730-0.903, p < 0.001), with
96% sensitivity, 65% specificity, and 94% negative predictive value (NPV). The
corresponding values for the Valsalva ratio (VR) were 62%, 92%, and 85%,
respectively. The 30:15 ratio was the strongest independent predictor of
neuropathy in multivariate regression analysis; low levels yielded an odds ratio
(OR) of 21.14 for CAN. The rise in diastolic blood pressure and the
expiration/inspiration/VR ratio (E/I/VR) were also identified as independent
predictors of CAN, with 9.45 and 10.79 ORs, respectively. CONCLUSIONS: The 30:15
ratio has the best diagnostic accuracy, primarily in the exclusion of CAN, by
virtue of its very high sensitivity and NPV. If this ratio is positive for CAN,
the VR, the rise in diastolic blood pressure, and the E/I/VR may be useful to
increase diagnostic accuracy. This procedure is a simplified diagnostic approach
that merits further evaluation to enable wider screening for CAN.
|Aged
[MESH]
|Autonomic Nervous System Diseases/*diagnosis/etiology/physiopathology
[MESH]
|Blood Pressure/physiology
[MESH]
|Diabetes Mellitus, Type 2/*complications/physiopathology
[MESH]