Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/srep46324 http://scihub22266oqcxt.onion/10.1038/srep46324 C5397870!5397870 !28425440     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28425440 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 46324 Nephropedia Template TP {{tp|p=28425440 |t=2017. The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo |pdf=|usr=}}{{28425440 }} gab.com Text The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28425440 #FOAvip The valosin-containing protein (VCP) participates in signaling pathways essential for cell homeostasis in multiple tissues, however, its function in the heart in vivo remains unknown. Here we offer the first description of the expression, function and mechanism of action of VCP in the mammalian heart in vivo in both normal and stress conditions. By using a transgenic (TG) mouse with cardiac-specific overexpression (3.5-fold) of VCP, we demonstrate that VCP is a new and powerful mediator of cardiac protection against cell death in vivo, as evidenced by a 50% reduction of infarct size after ischemia/reperfusion versus wild type. We also identify a novel role of VCP in preserving mitochondrial respiration and in preventing the opening of mitochondrial permeability transition pore in cardiac myocytes under stress. In particular, by genetic deletion of inducible isoform of nitric oxide synthase (iNOS) from VCP TG mouse and by pharmacological inhibition of iNOS in isolated cardiac myocytes, we reveal that an increase of expression and activity of iNOS in cardiomyocytes by VCP is an essential mechanistic link of VCP-mediated preservation of mitochondrial function. These data together demonstrate that VCP may represent a novel therapeutic avenue for the prevention of myocardial ischemia. Twit Text FOAVip The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28425440 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28425440 #FOAvip English Wikipedia <ref>{{Cite pmid|28425440 }}</ref> The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo #MMPMID28425440 Lizano P ; Rashed E ; Stoll S ; Zhou N ; Wen H ; Hays TT ; Qin G ; Xie LH ; Depre C ; Qiu H Sci Rep 2017[Apr]; 7 (ä): 46324 PMID28425440 show ga The valosin-containing protein (VCP) participates in signaling pathways essential for cell homeostasis in multiple tissues, however, its function in the heart in vivo remains unknown. Here we offer the first description of the expression, function and mechanism of action of VCP in the mammalian heart in vivo in both normal and stress conditions. By using a transgenic (TG) mouse with cardiac-specific overexpression (3.5-fold) of VCP, we demonstrate that VCP is a new and powerful mediator of cardiac protection against cell death in vivo, as evidenced by a 50% reduction of infarct size after ischemia/reperfusion versus wild type. We also identify a novel role of VCP in preserving mitochondrial respiration and in preventing the opening of mitochondrial permeability transition pore in cardiac myocytes under stress. In particular, by genetic deletion of inducible isoform of nitric oxide synthase (iNOS) from VCP TG mouse and by pharmacological inhibition of iNOS in isolated cardiac myocytes, we reveal that an increase of expression and activity of iNOS in cardiomyocytes by VCP is an essential mechanistic link of VCP-mediated preservation of mitochondrial function. These data together demonstrate that VCP may represent a novel therapeutic avenue for the prevention of myocardial ischemia. |*Cell Respiration/genetics [MESH] |*Cell Survival/genetics [MESH] |Adenosine Diphosphate/metabolism [MESH] |Animals [MESH] |Biomarkers [MESH] |Female [MESH] |Gene Deletion [MESH] |Gene Expression [MESH] |Male [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Mitochondria/genetics/*metabolism [MESH] |Mitochondrial Membrane Transport Proteins/genetics/metabolism [MESH] |Mitochondrial Permeability Transition Pore [MESH] |Models, Biological [MESH] |Myocardial Reperfusion Injury/genetics/metabolism/pathology [MESH] |Myocardium/*metabolism [MESH] |Myocytes, Cardiac/metabolism [MESH] |Nitric Oxide Synthase Type II/genetics/metabolism [MESH] |Oxygen Consumption [MESH]The valosin-containing protein is a novel mediator of mitochondrial re(epmc).pdf DeepDyve Pubget Overpricing