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10.1038/srep46580 http://scihub22266oqcxt.onion/10.1038/srep46580 C5397865!5397865 !28425456     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28425456 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 46580 Nephropedia Template TP {{tp|p=28425456 |t=2017. Salt suppresses IFN? inducible chemokines through the IFN?-JAK1-STAT1 signaling pathway in proximal tubular cells |pdf=|usr=}}{{28425456 }} gab.com Text Salt suppresses IFN inducible chemokines through the IFN -JAK1-STAT1 signaling pathway in proximal tubular cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28425456 #FOAvip The mechanisms of immunoactivation by salt are now becoming clearer. However, those of immunosuppression remain unknown. Since clinical evidence indicates that salt protects proximal tubules from injury, we investigated mechanisms responsible for salt causing immunosuppression in proximal tubules. We focused on cytokine-related gene expression profiles in kidneys of mice fed a high salt diet using microarray analysis and found that both an interferon gamma (IFN?) inducible chemokine, chemokine (C-X-C motif) ligand 9 (CXCL9), and receptor, CXCR3, were suppressed. We further revealed that a high salt concentration suppressed IFN? inducible chemokines in HK2 proximal tubular cells. Finally, we demonstrated that a high salt concentration decreased IFNGR1 expression in the basolateral membrane of HK2 cells, leading to decreased phosphorylation of activation sites of Janus kinase 1 (JAK1) and Signal Transducers and Activator of Transcription 1 (STAT1), activators of chemokines. JAK inhibitor canceled the effect of a high salt concentration on STAT1 and chemokines, indicating that the JAK1-STAT1 signaling pathway is essential for this mechanism. In conclusion, a high salt concentration suppresses IFN?-JAK1-STAT1 signaling pathways and chemokine expressions in proximal tubules. This finding may explain how salt ameliorates proximal tubular injury and offer a new insight into the linkage between salt and immunity. Twit Text FOAVip Salt suppresses IFN inducible chemokines through the IFN -JAK1-STAT1 signaling pathway in proximal tubular cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28425456 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28425456 #FOAvip English Wikipedia <ref>{{Cite pmid|28425456 }}</ref> Salt suppresses IFN? inducible chemokines through the IFN?-JAK1-STAT1 signaling pathway in proximal tubular cells #MMPMID28425456 Arai Y ; Takahashi D ; Asano K ; Tanaka M ; Oda M ; Ko SBH ; Ko MSH ; Mandai S ; Nomura N ; Rai T ; Uchida S ; Sohara E Sci Rep 2017[Apr]; 7 (ä): 46580 PMID28425456 show ga The mechanisms of immunoactivation by salt are now becoming clearer. However, those of immunosuppression remain unknown. Since clinical evidence indicates that salt protects proximal tubules from injury, we investigated mechanisms responsible for salt causing immunosuppression in proximal tubules. We focused on cytokine-related gene expression profiles in kidneys of mice fed a high salt diet using microarray analysis and found that both an interferon gamma (IFN?) inducible chemokine, chemokine (C-X-C motif) ligand 9 (CXCL9), and receptor, CXCR3, were suppressed. We further revealed that a high salt concentration suppressed IFN? inducible chemokines in HK2 proximal tubular cells. Finally, we demonstrated that a high salt concentration decreased IFNGR1 expression in the basolateral membrane of HK2 cells, leading to decreased phosphorylation of activation sites of Janus kinase 1 (JAK1) and Signal Transducers and Activator of Transcription 1 (STAT1), activators of chemokines. JAK inhibitor canceled the effect of a high salt concentration on STAT1 and chemokines, indicating that the JAK1-STAT1 signaling pathway is essential for this mechanism. In conclusion, a high salt concentration suppresses IFN?-JAK1-STAT1 signaling pathways and chemokine expressions in proximal tubules. This finding may explain how salt ameliorates proximal tubular injury and offer a new insight into the linkage between salt and immunity. |Animals [MESH] |Antiviral Agents/pharmacology [MESH] |Cell Line [MESH] |Chemokines/*genetics/metabolism [MESH] |Epithelial Cells/*drug effects/metabolism [MESH] |Humans [MESH] |Interferon gamma Receptor [MESH] |Interferon-gamma/metabolism/*pharmacology [MESH] |Janus Kinase 1/metabolism [MESH] |Kidney Tubules, Proximal/cytology [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Receptors, Interferon/genetics/metabolism [MESH] |STAT1 Transcription Factor/metabolism [MESH] |Signal Transduction/*drug effects/genetics [MESH] |Sodium Chloride/*pharmacology [MESH]Salt suppresses IFN? inducible chemokines through the IFN?-JAK1-STAT1 (epmc).pdf DeepDyve Pubget Overpricing