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10.1016/j.ajpath.2016.11.007 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2016.11.007 C5397667!5397667!28162229     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol 2017 ; 187 (3): 627-38 Nephropedia Template TP {{tp|p=28162229|t=2017. The Increased Transforming Growth Factor-? Signaling Induced by Diabetes Protects Retinal Vessels |pdf=|usr=}}{{28162229}} gab.com Text The Increased Transforming Growth Factor- Signaling Induced by Diabetes Protects Retinal Vessels JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=28162229 #FOAvip The roles of transforming growth factor (TGF)-? in extracellular matrix production and vascular remodeling, coupled with increased TGF-? expression and signaling in diabetes, suggest TGF-? as an important contributor to the microangiopathy of diabetic retinopathy and nephropathy. To investigate whether increased TGF-? signaling could be a therapeutic target for preventing retinopathy, we used a pharmacologic approach (SM16, a selective inhibitor of the type 1 TGF-? receptor activin receptor?like kinase 5, orally active) to inhibit the increased, but not the basal, Tgf-? signaling in retinal vessels of diabetic rats. At the level of vascular gene expression, 3.5 months' diabetes induced minimal changes. Diabetes + SM16 for 3 weeks caused widespread changes in gene expression poised to enhance vascular inflammation, thrombosis, leakage, and wall instability; these changes were not observed in control rats given SM16. The synergy of diabetes and SM16 in altering gene expression was not observed in the lung. At the level of vascular network morphology, 7 months' diabetes induced no detectable changes. Diabetes + SM16 for 3 weeks caused instead distorted morphology and decreased density. Thus, in diabetes, retinal vessels become dependent on a small increase in TGF-? signaling via activin receptor?like kinase 5 to maintain early integrity. The increased TGF-? signaling may protect against rapid retinopathy progression and should not be a target of inhibitory interventions. Twit Text FOAVip The Increased Transforming Growth Factor- Signaling Induced by Diabetes Protects Retinal Vessels ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=28162229 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28162229 #FOAvip English Wikipedia <ref>{{Cite pmid|28162229}}</ref> The Increased Transforming Growth Factor-? Signaling Induced by Diabetes Protects Retinal Vessels #MMPMID28162229 Dagher Z; Gerhardinger C; Vaz J; Goodridge M; Tecilazich F; Lorenzi M Am J Pathol 2017[Mar]; 187 (3): 627-38 PMID28162229show ga The roles of transforming growth factor (TGF)-? in extracellular matrix production and vascular remodeling, coupled with increased TGF-? expression and signaling in diabetes, suggest TGF-? as an important contributor to the microangiopathy of diabetic retinopathy and nephropathy. To investigate whether increased TGF-? signaling could be a therapeutic target for preventing retinopathy, we used a pharmacologic approach (SM16, a selective inhibitor of the type 1 TGF-? receptor activin receptor?like kinase 5, orally active) to inhibit the increased, but not the basal, Tgf-? signaling in retinal vessels of diabetic rats. At the level of vascular gene expression, 3.5 months' diabetes induced minimal changes. Diabetes + SM16 for 3 weeks caused widespread changes in gene expression poised to enhance vascular inflammation, thrombosis, leakage, and wall instability; these changes were not observed in control rats given SM16. The synergy of diabetes and SM16 in altering gene expression was not observed in the lung. At the level of vascular network morphology, 7 months' diabetes induced no detectable changes. Diabetes + SM16 for 3 weeks caused instead distorted morphology and decreased density. Thus, in diabetes, retinal vessels become dependent on a small increase in TGF-? signaling via activin receptor?like kinase 5 to maintain early integrity. The increased TGF-? signaling may protect against rapid retinopathy progression and should not be a target of inhibitory interventions. äThe Increased Transforming Growth Factor-? Signaling Induced by Diabet(epmc).pdf DeepDyve Pubget Overpricing