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10.1016/j.biopsych.2015.10.009 http://scihub22266oqcxt.onion/10.1016/j.biopsych.2015.10.009 C5397584!5397584!26681495     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biol+Psychiatry 2016 ; 80 (4): 284-92 Nephropedia Template TP {{tp|p=26681495|t=2016. Genetic markers of human evolution are enriched in schizophrenia |pdf=|usr=}}{{26681495}} gab.com Text Genetic markers of human evolution are enriched in schizophrenia JO: Biol Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=26681495 #FOAvip Background: Why schizophrenia has accompanied us throughout our history despite its negative effect on fitness remains an evolutionary enigma. It is proposed that schizophrenia is a by-product of the complex evolution of the human brain and a compromise for our language, creative thinking and cognitive abilities. Method: We analyze recent large genome-wide association studies of schizophrenia and a range of other human phenotypes (anthropometric measures, cardiovascular disease risk factors, immune-mediated diseases) using a statistical framework that draws on polygenic architecture and ancillary information on genetic variants. We used information from the evolutionary proxy measure called Neanderthal selective sweep (NSS) score. Results: We show that gene loci associated with schizophrenia are significantly (p = 7.30×10?9) more prevalent in genomic regions that are likely to have undergone recent positive selection in humans, i.e. with low NSS score. Variants in brain-related genes with low NSS score confer significantly higher susceptibility than variants in other brain-related genes. The enrichment is strongest for schizophrenia, but we cannot rule out enrichment for other phenotypes. The false discovery rate conditional on the evolutionary proxy, points to 27 candidate schizophrenia susceptibility loci, twelve of which are associated with schizophrenia and other psychiatric disorders, or linked to brain development. Conclusion: The results suggest that there is a polygenic overlap between schizophrenia and NSS score, a marker of human evolution, which is in line with the hypothesis that the persistence of schizophrenia is related to the evolutionary process of becoming human. Twit Text FOAVip Genetic markers of human evolution are enriched in schizophrenia ????Biol Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=26681495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26681495 #FOAvip English Wikipedia <ref>{{Cite pmid|26681495}}</ref> Genetic markers of human evolution are enriched in schizophrenia #MMPMID26681495 Srinivasan S; Bettella F; Mattingsdal M; Wang Y; Witoelar A; Schork AJ; Thompson WK; Zuber V; Winsvold BS; Zwart JA; Collier DA; Desikan RS; Melle I; Werge T; Dale AM; Djurovic S; Andreassen OA Biol Psychiatry 2016[Aug]; 80 (4): 284-92 PMID26681495show ga Background: Why schizophrenia has accompanied us throughout our history despite its negative effect on fitness remains an evolutionary enigma. It is proposed that schizophrenia is a by-product of the complex evolution of the human brain and a compromise for our language, creative thinking and cognitive abilities. Method: We analyze recent large genome-wide association studies of schizophrenia and a range of other human phenotypes (anthropometric measures, cardiovascular disease risk factors, immune-mediated diseases) using a statistical framework that draws on polygenic architecture and ancillary information on genetic variants. We used information from the evolutionary proxy measure called Neanderthal selective sweep (NSS) score. Results: We show that gene loci associated with schizophrenia are significantly (p = 7.30×10?9) more prevalent in genomic regions that are likely to have undergone recent positive selection in humans, i.e. with low NSS score. Variants in brain-related genes with low NSS score confer significantly higher susceptibility than variants in other brain-related genes. The enrichment is strongest for schizophrenia, but we cannot rule out enrichment for other phenotypes. The false discovery rate conditional on the evolutionary proxy, points to 27 candidate schizophrenia susceptibility loci, twelve of which are associated with schizophrenia and other psychiatric disorders, or linked to brain development. Conclusion: The results suggest that there is a polygenic overlap between schizophrenia and NSS score, a marker of human evolution, which is in line with the hypothesis that the persistence of schizophrenia is related to the evolutionary process of becoming human. äGenetic markers of human evolution are enriched in schizophrenia (epmc).pdf DeepDyve Pubget Overpricing