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10.1093/nar/gkw1283 http://scihub22266oqcxt.onion/10.1093/nar/gkw1283 C5397169!5397169 !27994038     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27994038 &cmd=llinks): Failed to open stream: HTTP request failed! 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Inducible super-enhancers are organized based on canonical signal-specific transcription factor binding elements |pdf=|usr=}}{{27994038 }} gab.com Text Inducible super-enhancers are organized based on canonical signal-specific transcription factor binding elements JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27994038 #FOAvip Super-enhancers are established through the interactions of several enhancers and a large number of proteins, including transcription factors and co-regulators; however, the formation of these interactions is poorly understood. By re-analysing previously published estrogen receptor alpha (ER?) ChIP-seq data sets derived from the MCF-7 cell line, we observed that in the absence of stimulation, future super-enhancers are represented by one or a few transcription factor binding event(s) and these extraordinary enhancers possess a response element largely specific to the ER? dimer. Upon hormonal stimulation, these primary binding sites are surrounded by a large amount of ER? and the critical components of active enhancers, such as P300 and MED1, and together with neighbouring sites bound by newly recruited ER?, they generate the functional super-enhancers. To further validate the role of canonical elements in super-enhancer formation, we investigated some additional signal-dependent transcription factors, confirming that certain, distinguished binding elements have a general organizer function. These results suggest that certain signal-specific transcription factors guide super-enhancer formation upon binding to strong response elements. These findings may reshape the current understanding of how these regulatory units assemble, highlighting the involvement of DNA elements instead of protein-protein interactions. Twit Text FOAVip Inducible super-enhancers are organized based on canonical signal-specific transcription factor binding elements ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27994038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27994038 #FOAvip English Wikipedia <ref>{{Cite pmid|27994038 }}</ref> Inducible super-enhancers are organized based on canonical signal-specific transcription factor binding elements #MMPMID27994038 Bojcsuk D ; Nagy G ; Balint BL Nucleic Acids Res 2017[Apr]; 45 (7 ): 3693-3706 PMID27994038 show ga Super-enhancers are established through the interactions of several enhancers and a large number of proteins, including transcription factors and co-regulators; however, the formation of these interactions is poorly understood. By re-analysing previously published estrogen receptor alpha (ER?) ChIP-seq data sets derived from the MCF-7 cell line, we observed that in the absence of stimulation, future super-enhancers are represented by one or a few transcription factor binding event(s) and these extraordinary enhancers possess a response element largely specific to the ER? dimer. Upon hormonal stimulation, these primary binding sites are surrounded by a large amount of ER? and the critical components of active enhancers, such as P300 and MED1, and together with neighbouring sites bound by newly recruited ER?, they generate the functional super-enhancers. To further validate the role of canonical elements in super-enhancer formation, we investigated some additional signal-dependent transcription factors, confirming that certain, distinguished binding elements have a general organizer function. These results suggest that certain signal-specific transcription factors guide super-enhancer formation upon binding to strong response elements. These findings may reshape the current understanding of how these regulatory units assemble, highlighting the involvement of DNA elements instead of protein-protein interactions. |*Enhancer Elements, Genetic [MESH] |Animals [MESH] |Binding Sites [MESH] |Cell Line, Tumor [MESH] |Cells, Cultured [MESH] |Estrogen Receptor alpha/metabolism [MESH] |Hepatocyte Nuclear Factor 3-alpha/metabolism [MESH] |Humans [MESH] |MCF-7 Cells [MESH] |Mice [MESH] |Signal Transduction [MESH] |Transcription Factor AP-2/metabolism [MESH]Inducible super-enhancers are organized based on canonical signal-spec(epmc).pdf DeepDyve Pubget Overpricing