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10.2147/OTT.S124008 http://scihub22266oqcxt.onion/10.2147/OTT.S124008 C5396947!5396947!28442918     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Onco+Targets+Ther 2017 ; 10 (ä): 2097-106 Nephropedia Template TP {{tp|p=28442918|t=2017. Targeting the PD-1 pathway in pediatric solid tumors and brain tumors |pdf=|usr=}}{{28442918}} gab.com Text Targeting the PD-1 pathway in pediatric solid tumors and brain tumors JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=28442918 #FOAvip While remarkable advances have been made in the treatment of pediatric leukemia over the past decades, new therapies are needed for children with advanced solid tumors and high-grade brain tumors who fail standard chemotherapy regimens. Immunotherapy with immune checkpoint inhibitors acting through the programmed cell death-1 (PD-1) pathway has shown efficacy in some chemotherapy-resistant adult cancers, generating interest that these agents may also be helpful to treat certain refractory pediatric malignancies. In this manuscript we review current strategies for targeting the PD-1 pathway, highlighting putative biomarkers and the rationale for investigation of these drugs to treat common pediatric tumors such as sarcoma, neuroblastoma, and high-grade glioma. We summarize the completed and ongoing clinical trial data available, and suggest potential applications for further study. Twit Text FOAVip Targeting the PD-1 pathway in pediatric solid tumors and brain tumors ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=28442918 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28442918 #FOAvip English Wikipedia <ref>{{Cite pmid|28442918}}</ref> Targeting the PD-1 pathway in pediatric solid tumors and brain tumors #MMPMID28442918 Wagner LM; Adams VR Onco Targets Ther 2017[]; 10 (ä): 2097-106 PMID28442918show ga While remarkable advances have been made in the treatment of pediatric leukemia over the past decades, new therapies are needed for children with advanced solid tumors and high-grade brain tumors who fail standard chemotherapy regimens. Immunotherapy with immune checkpoint inhibitors acting through the programmed cell death-1 (PD-1) pathway has shown efficacy in some chemotherapy-resistant adult cancers, generating interest that these agents may also be helpful to treat certain refractory pediatric malignancies. In this manuscript we review current strategies for targeting the PD-1 pathway, highlighting putative biomarkers and the rationale for investigation of these drugs to treat common pediatric tumors such as sarcoma, neuroblastoma, and high-grade glioma. We summarize the completed and ongoing clinical trial data available, and suggest potential applications for further study. äTargeting the PD-1 pathway in pediatric solid tumors and brain tumors (epmc).pdf DeepDyve Pubget Overpricing