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Sleep duration and quality in relation to chronic kidney disease and glomerular
hyperfiltration in healthy men and women
#MMPMID28423054
Kim CW
; Chang Y
; Sung E
; Yun KE
; Jung HS
; Ko BJ
; Kwon MJ
; Hyun YY
; Lee KB
; Kim H
; Shin H
; Ryu S
PLoS One
2017[]; 12
(4
): e0175298
PMID28423054
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BACKGROUND: It is unclear whether sleep duration and quality are associated with
chronic kidney disease (CKD) and glomerular hyperfiltration. The aim of this
study was to examine the association of sleep duration and quality with CKD and
glomerular hyperfiltration in young and middle-aged adults. METHODS: We conducted
a cross-sectional study of men and women who underwent a health checkup
examination, including assessment of sleep duration and quality (n = 241,607).
Chronic kidney disease (CKD) was defined as an estimated glomerular filtration
rate (eGFR) less than 60 ml/min/1.73 m2, and glomerular hyperfiltration was
defined as eGFR above the age-/sex-specific 95th percentile. RESULTS: In a
multinomial logistic regression analysis adjusting for relevant confounders, the
adjusted prevalence ratios for CKD (95% confidence interval) comparing sleep
durations of ? 5, 6, 8, and 9 hours with 7 hours were 1.22 (0.95-1.55), 0.93
(0.75-1.14), 0.97 (0.75-1.26), and 1.56 (1.06-2.30) in men and 0.98 (0.68-1.43),
1.03 (0.72-1.46), 1.39 (0.97-2.00), and 1.31 (0.78-2.22) in women, respectively.
The corresponding prevalence ratios (95% confidence interval) for glomerular
hyperfiltration were 1.00 (0.93-1.08), 0.97 (0.91-1.03), 1.03 (0.94-1.13), and
1.39 (1.13-1.72) in men and 1.04 (0.95-1.14), 0.96 (0.90-1.04), 1.11 (1.02-1.20),
and 1.28 (1.14-1.45) in women, respectively. Poor subjective sleep quality was
associated with glomerular hyperfiltration in men and women. CONCLUSION: In this
large study of young and middle-aged adults, we found that long sleep duration
was associated with CKD and glomerular hyperfiltration. Additionally, poor
subjective sleep quality was associated with increased prevalence of glomerular
hyperfiltration, suggesting the importance of adequate quantity and quality of
sleep for kidney function.
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