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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2017 ; 12
(4
): e0171379
Nephropedia Template TP
gab.com Text
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English Wikipedia
Low cholesterol level associated with severity and outcome of spontaneous
intracerebral hemorrhage: Results from Taiwan Stroke Registry
#MMPMID28422955
Chen YW
; Li CH
; Yang CD
; Liu CH
; Chen CH
; Sheu JJ
; Lin SK
; Chen AC
; Chen PK
; Chen PL
; Yeh CH
; Chen JR
; Hsiao YJ
; Lin CH
; Hsu SP
; Chen TS
; Sung SF
; Yu SC
; Muo CH
; Wen CP
; Sung FC
; Jeng JS
; Hsu CY
PLoS One
2017[]; 12
(4
): e0171379
PMID28422955
show ga
The relationship between cholesterol level and hemorrhagic stroke is
inconclusive. We hypothesized that low cholesterol levels may have association
with intracerebral hemorrhage (ICH) severity at admission and 3-month outcomes.
This study used data obtained from a multi-center stroke registry program in
Taiwan. We categorized acute spontaneous ICH patients, based on their baseline
levels of total cholesterol (TC) measured at admission, into 3 groups with <160,
160-200 and >200 mg/dL of TC. We evaluated risk of having initial stroke
severity, with National Institutes of Health Stroke Scale (NIHSS) >15 and
unfavorable outcomes (modified Rankin Scale [mRS] score >2, 3-month mortality)
after ICH by the TC group. A total of 2444 ICH patients (mean age 62.5±14.2
years; 64.2% men) were included in this study and 854 (34.9%) of them had
baseline TC <160 mg/dL. Patients with TC <160 mg/dL presented more often severe
neurological deficit (NIHSS >15), with an adjusted odds ratio [aOR] of 1.80; 95%
confidence interval [CI], 1.41-2.30), and 3-month mRS >2 (aOR, 1.41; 95% CI,
1.11-1.78) using patients with TC >200 mg/dL as reference. Those with TC >160
mg/dL and body mass index (BMI) <22 kg/m2 had higher risk of 3-month mortality
(aOR 3.94, 95% CI 1.76-8.80). Prior use of lipid-lowering drugs (2.8% of the ICH
population) was not associated with initial severity and 3-month outcomes. A
total cholesterol level lower than 160 mg/dL was common in patients with acute
ICH and was associated with greater neurological severity on presentation and
poor 3-month outcomes, especially with lower BMI.