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10.1371/journal.pone.0171379

http://scihub22266oqcxt.onion/10.1371/journal.pone.0171379
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suck abstract from ncbi


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pmid28422955
      PLoS+One 2017 ; 12 (4 ): e0171379
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  • Low cholesterol level associated with severity and outcome of spontaneous intracerebral hemorrhage: Results from Taiwan Stroke Registry #MMPMID28422955
  • Chen YW ; Li CH ; Yang CD ; Liu CH ; Chen CH ; Sheu JJ ; Lin SK ; Chen AC ; Chen PK ; Chen PL ; Yeh CH ; Chen JR ; Hsiao YJ ; Lin CH ; Hsu SP ; Chen TS ; Sung SF ; Yu SC ; Muo CH ; Wen CP ; Sung FC ; Jeng JS ; Hsu CY
  • PLoS One 2017[]; 12 (4 ): e0171379 PMID28422955 show ga
  • The relationship between cholesterol level and hemorrhagic stroke is inconclusive. We hypothesized that low cholesterol levels may have association with intracerebral hemorrhage (ICH) severity at admission and 3-month outcomes. This study used data obtained from a multi-center stroke registry program in Taiwan. We categorized acute spontaneous ICH patients, based on their baseline levels of total cholesterol (TC) measured at admission, into 3 groups with <160, 160-200 and >200 mg/dL of TC. We evaluated risk of having initial stroke severity, with National Institutes of Health Stroke Scale (NIHSS) >15 and unfavorable outcomes (modified Rankin Scale [mRS] score >2, 3-month mortality) after ICH by the TC group. A total of 2444 ICH patients (mean age 62.5±14.2 years; 64.2% men) were included in this study and 854 (34.9%) of them had baseline TC <160 mg/dL. Patients with TC <160 mg/dL presented more often severe neurological deficit (NIHSS >15), with an adjusted odds ratio [aOR] of 1.80; 95% confidence interval [CI], 1.41-2.30), and 3-month mRS >2 (aOR, 1.41; 95% CI, 1.11-1.78) using patients with TC >200 mg/dL as reference. Those with TC >160 mg/dL and body mass index (BMI) <22 kg/m2 had higher risk of 3-month mortality (aOR 3.94, 95% CI 1.76-8.80). Prior use of lipid-lowering drugs (2.8% of the ICH population) was not associated with initial severity and 3-month outcomes. A total cholesterol level lower than 160 mg/dL was common in patients with acute ICH and was associated with greater neurological severity on presentation and poor 3-month outcomes, especially with lower BMI.
  • |*Registries [MESH]
  • |Aged [MESH]
  • |Anticholesteremic Agents/*therapeutic use [MESH]
  • |Anticoagulants/*therapeutic use [MESH]
  • |Antihypertensive Agents/*therapeutic use [MESH]
  • |Body Mass Index [MESH]
  • |Cerebral Hemorrhage/blood/diagnosis/*drug therapy/mortality [MESH]
  • |Cholesterol/blood [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Hypercholesterolemia/blood/diagnosis/*drug therapy/mortality [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Prospective Studies [MESH]
  • |Risk [MESH]
  • |Severity of Illness Index [MESH]
  • |Stroke/blood/diagnosis/*drug therapy/mortality [MESH]
  • |Survival Analysis [MESH]
  • |Taiwan [MESH]


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