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10.1007/s41061-017-0106-y http://scihub22266oqcxt.onion/10.1007/s41061-017-0106-y C5396385!5396385!28116583     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Top+Curr+Chem+(Cham) 2017 ; 375 (1): ä Nephropedia Template TP {{tp|p=28116583|t=2017. Applications of Phosphate Modification and Labeling to Study (m)RNA Caps |pdf=|usr=}}{{28116583}} gab.com Text Applications of Phosphate Modification and Labeling to Study (m)RNA Caps JO: Top Curr Chem (Cham) http://www.kidney.de/pget.php?&tw=1&pmid=28116583 #FOAvip The cap is a natural modification present at the 5? ends of eukaryotic messenger RNA (mRNA), which because of its unique structural features, mediates essential biological functions during the process of gene expression. The core structural feature of the mRNA cap is an N7-methylguanosine moiety linked by a 5??5? triphosphate chain to the first transcribed nucleotide. Interestingly, other RNA 5? end modifications structurally and functionally resembling the m7G cap have been discovered in different RNA types and in different organisms. All these structures contain the ?inverted? 5??5? oligophosphate bridge, which is necessary for interaction with specific proteins and also serves as a cleavage site for phosphohydrolases regulating RNA turnover. Therefore, cap analogs containing oligophosphate chain modifications or carrying spectroscopic labels attached to phosphate moieties serve as attractive molecular tools for studies on RNA metabolism and modification of natural RNA properties. Here, we review chemical, enzymatic, and chemoenzymatic approaches that enable preparation of modified cap structures and RNAs carrying such structures, with emphasis on phosphate-modified mRNA cap analogs and their potential applications. Twit Text FOAVip Applications of Phosphate Modification and Labeling to Study (m)RNA Caps ????Top Curr Chem (Cham) http://www.kidney.de/pget.php?&tw=1&pmid=28116583 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28116583 #FOAvip English Wikipedia <ref>{{Cite pmid|28116583}}</ref> Applications of Phosphate Modification and Labeling to Study (m)RNA Caps #MMPMID28116583 Warminski M; Sikorski PJ; Kowalska J; Jemielity J Top Curr Chem (Cham) 2017[]; 375 (1): ä PMID28116583show ga The cap is a natural modification present at the 5? ends of eukaryotic messenger RNA (mRNA), which because of its unique structural features, mediates essential biological functions during the process of gene expression. The core structural feature of the mRNA cap is an N7-methylguanosine moiety linked by a 5??5? triphosphate chain to the first transcribed nucleotide. Interestingly, other RNA 5? end modifications structurally and functionally resembling the m7G cap have been discovered in different RNA types and in different organisms. All these structures contain the ?inverted? 5??5? oligophosphate bridge, which is necessary for interaction with specific proteins and also serves as a cleavage site for phosphohydrolases regulating RNA turnover. Therefore, cap analogs containing oligophosphate chain modifications or carrying spectroscopic labels attached to phosphate moieties serve as attractive molecular tools for studies on RNA metabolism and modification of natural RNA properties. Here, we review chemical, enzymatic, and chemoenzymatic approaches that enable preparation of modified cap structures and RNAs carrying such structures, with emphasis on phosphate-modified mRNA cap analogs and their potential applications. äApplications of Phosphate Modification and Labeling to Study (m)RNA Ca(epmc).pdf DeepDyve Pubget Overpricing