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10.1111/1756-185X.12901 http://scihub22266oqcxt.onion/10.1111/1756-185X.12901 C5396326!5396326 !27451980     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27451980 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Rheum+Dis 2016 ; 19 (12 ): 1216-1225 Nephropedia Template TP {{tp|p=27451980 |t=2016. Efficacy and safety of tofacitinib in patients with active rheumatoid arthritis: review of key Phase 2 studies |pdf=|usr=}}{{27451980 }} gab.com Text Efficacy and safety of tofacitinib in patients with active rheumatoid arthritis: review of key Phase 2 studies JO: Int J Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=27451980 #FOAvip Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Here, the safety and efficacy data from five Phase 2 studies of tofacitinib in patients with RA are summarized. Tofacitinib 1-30 mg twice daily was investigated, as monotherapy and in combination with methotrexate, in patients with RA. Tofacitinib 20 mg once daily was investigated in one study. Tofacitinib 5 and 10 mg twice daily were selected for investigation in Phase 3 studies; therefore, the efficacy and safety of tofacitinib 5 and 10 mg twice daily in Phase 2 studies are the focus of this review. Tofacitinib ? 5 mg twice daily was efficacious in a dose-dependent manner, with statistically significant and clinically meaningful reductions in the signs and symptoms of RA and patient-reported outcomes. The safety profile was consistent across studies. The efficacy and safety profile of tofacitinib in Phase 2 studies supported its further investigation and the selection of tofacitinib 5 mg twice daily and tofacitinib 10 mg twice daily for evaluation in Phase 3 studies. Twit Text FOAVip Efficacy and safety of tofacitinib in patients with active rheumatoid arthritis: review of key Phase 2 studies ????Int J Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=27451980 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27451980 #FOAvip English Wikipedia <ref>{{Cite pmid|27451980 }}</ref> Efficacy and safety of tofacitinib in patients with active rheumatoid arthritis: review of key Phase 2 studies #MMPMID27451980 Fleischmann R ; Kremer J ; Tanaka Y ; Gruben D ; Kanik K ; Koncz T ; Krishnaswami S ; Wallenstein G ; Wilkinson B ; Zwillich SH ; Keystone E Int J Rheum Dis 2016[Dec]; 19 (12 ): 1216-1225 PMID27451980 show ga Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Here, the safety and efficacy data from five Phase 2 studies of tofacitinib in patients with RA are summarized. Tofacitinib 1-30 mg twice daily was investigated, as monotherapy and in combination with methotrexate, in patients with RA. Tofacitinib 20 mg once daily was investigated in one study. Tofacitinib 5 and 10 mg twice daily were selected for investigation in Phase 3 studies; therefore, the efficacy and safety of tofacitinib 5 and 10 mg twice daily in Phase 2 studies are the focus of this review. Tofacitinib ? 5 mg twice daily was efficacious in a dose-dependent manner, with statistically significant and clinically meaningful reductions in the signs and symptoms of RA and patient-reported outcomes. The safety profile was consistent across studies. The efficacy and safety profile of tofacitinib in Phase 2 studies supported its further investigation and the selection of tofacitinib 5 mg twice daily and tofacitinib 10 mg twice daily for evaluation in Phase 3 studies. |Antirheumatic Agents/*administration & dosage/adverse effects [MESH] |Arthritis, Rheumatoid/diagnosis/*drug therapy/enzymology [MESH] |Clinical Trials, Phase II as Topic [MESH] |Dose-Response Relationship, Drug [MESH] |Drug Administration Schedule [MESH] |Drug Therapy, Combination [MESH] |Female [MESH] |Humans [MESH] |Janus Kinases/*antagonists & inhibitors/metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Piperidines/*administration & dosage/adverse effects [MESH] |Protein Kinase Inhibitors/*administration & dosage/adverse effects [MESH] |Pyrimidines/*administration & dosage/adverse effects [MESH] |Pyrroles/*administration & dosage/adverse effects [MESH] |Randomized Controlled Trials as Topic [MESH] |Remission Induction [MESH]Efficacy and safety of tofacitinib in patients with active rheumatoid (epmc).pdf DeepDyve Pubget Overpricing