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10.1038/srep46541 http://scihub22266oqcxt.onion/10.1038/srep46541 C5396196!5396196!28422156     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28422156|t=2017. Anticancer properties of a defensin like class IId bacteriocin Laterosporulin10 |pdf=|usr=}}{{28422156}} gab.com Text Anticancer properties of a defensin like class IId bacteriocin Laterosporulin10 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28422156 #FOAvip Laterosporulin10 (LS10) is a defensin like peptide from Brevibacillus sp. strain SKDU10 that inhibited microbial pathogens. However, in this study, anticancer activity of LS10 was examined against different cancer cell lines and compared with normal cells. LS10 displayed cytotoxicity against cancer cells like MCF-7, HEK293T, HT1080, HeLa and H1299 at below 10??M concentration, but not against prostate epithelium cells RWPE-1. Additionally, no hemolysis was observed at significantly higher concentration compared to IC50 values observed for different cancer cell lines. Release of lactate dehydrogenase from cancer cell lines at 15??M concentration upon 120?min treatment indicated the lytic ability of LS10. Accordingly, electron microscopy experiments also confirmed the necrotic effect of LS10 at 15??M concentration against cancer cells. Furthermore, flow cytometry analysis of treated cancer cell lines revealed that LS10 induce apoptosis even at 2.5??M concentration. Nevertheless, RWPE-1 cells remained viable even at 20??M concentration. These results provide evidence that LS10 is an anticancer bacteriocin, which causes apoptotic and necrotic death of cancer cells at lower and higher concentrations, respectively. Taken all results together, the present study signifies that LS10 is an anticancer peptide that could be further developed for therapeutic applications. Twit Text FOAVip Anticancer properties of a defensin like class IId bacteriocin Laterosporulin10 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28422156 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28422156 #FOAvip English Wikipedia <ref>{{Cite pmid|28422156}}</ref> Anticancer properties of a defensin like class IId bacteriocin Laterosporulin10 #MMPMID28422156 Baindara P; Gautam A; Raghava GPS; Korpole S Sci Rep 2017[]; 7 (ä): ä PMID28422156show ga Laterosporulin10 (LS10) is a defensin like peptide from Brevibacillus sp. strain SKDU10 that inhibited microbial pathogens. However, in this study, anticancer activity of LS10 was examined against different cancer cell lines and compared with normal cells. LS10 displayed cytotoxicity against cancer cells like MCF-7, HEK293T, HT1080, HeLa and H1299 at below 10??M concentration, but not against prostate epithelium cells RWPE-1. Additionally, no hemolysis was observed at significantly higher concentration compared to IC50 values observed for different cancer cell lines. Release of lactate dehydrogenase from cancer cell lines at 15??M concentration upon 120?min treatment indicated the lytic ability of LS10. Accordingly, electron microscopy experiments also confirmed the necrotic effect of LS10 at 15??M concentration against cancer cells. Furthermore, flow cytometry analysis of treated cancer cell lines revealed that LS10 induce apoptosis even at 2.5??M concentration. Nevertheless, RWPE-1 cells remained viable even at 20??M concentration. These results provide evidence that LS10 is an anticancer bacteriocin, which causes apoptotic and necrotic death of cancer cells at lower and higher concentrations, respectively. Taken all results together, the present study signifies that LS10 is an anticancer peptide that could be further developed for therapeutic applications. äAnticancer properties of a defensin like class IId bacteriocin Lateros(epmc).pdf DeepDyve Pubget Overpricing