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10.4161/auto.27485 http://scihub22266oqcxt.onion/10.4161/auto.27485 C5396090!5396090!24362312     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2014 ; 10 (2): 386-7 Nephropedia Template TP {{tp|p=24362312|t=2014. Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A |pdf=|usr=}}{{24362312}} gab.com Text Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24362312 #FOAvip Cells respond to the deprivation of nutrients by inducing autophagy. However, mechanisms through which cells coordinately regulate autophagy with metabolic state remain incompletely understood. We previously observed that prototrophic strains of yeast induce autophagy upon switch from a rich to minimal medium in the absence of severe nitrogen starvation. We determined that the sulfur-containing amino acid methionine and its downstream metabolite S-adenosylmethionine (SAM) are sufficient to strongly inhibit such autophagy. These metabolites function through Ppm1, an enzyme that methylates the catalytic subunit of the protein phosphatase PP2A. As such, methionine and SAM act as critical signals of amino acid sufficiency that reciprocally regulate autophagy and cell growth by modulating the methylation status of PP2A. Twit Text FOAVip Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24362312 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24362312 #FOAvip English Wikipedia <ref>{{Cite pmid|24362312}}</ref> Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A #MMPMID24362312 Laxman S; Sutter BM; Tu BP Autophagy 2014[Feb]; 10 (2): 386-7 PMID24362312show ga Cells respond to the deprivation of nutrients by inducing autophagy. However, mechanisms through which cells coordinately regulate autophagy with metabolic state remain incompletely understood. We previously observed that prototrophic strains of yeast induce autophagy upon switch from a rich to minimal medium in the absence of severe nitrogen starvation. We determined that the sulfur-containing amino acid methionine and its downstream metabolite S-adenosylmethionine (SAM) are sufficient to strongly inhibit such autophagy. These metabolites function through Ppm1, an enzyme that methylates the catalytic subunit of the protein phosphatase PP2A. As such, methionine and SAM act as critical signals of amino acid sufficiency that reciprocally regulate autophagy and cell growth by modulating the methylation status of PP2A. äMethionine is a signal of amino acid sufficiency that inhibits autopha(epmc).pdf DeepDyve Pubget Overpricing