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10.3389/fnins.2017.00194 http://scihub22266oqcxt.onion/10.3389/fnins.2017.00194 C5395619!5395619!28469550     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28469550&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Front+Neurosci 2017 ; 11 (ä): ä Nephropedia Template TP {{tp|p=28469550|t=2017. Exosomes and the Prion Protein: More than One Truth |pdf=|usr=}}{{28469550}} gab.com Text Exosomes and the Prion Protein: More than One Truth JO: Front Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28469550 #FOAvip Exosomes are involved in the progression of neurodegenerative diseases. The cellular prion protein (PrPC) is highly expressed on exosomes. In neurodegenerative diseases, PrPC has at least two functions: It is the substrate for the generation of pathological prion protein (PrPSc), a key player in the pathophysiology of prion diseases. On the other hand, it binds neurotoxic amyloid-beta (Aß) oligomers, which are associated with initiation and progression of Alzheimer's disease (AD). This has direct consequences for the role of exosomal expressed PrPC. In prion diseases, exosomal PrP leads to efficient dissemination of pathological prion protein, thus promoting spreading and transmission of the disease. In AD, exosomal PrPC can bind and detoxify Aß oligomers thus acting protective. In both scenarios, assessment of the state of PrPC on exosomes derived from blood or cerebrospinal fluid (CSF) may be useful for diagnostic workup of these diseases. This review sums up current knowledge of the role of exosomal PrPC on different aspects of Alzheimer's and prion disease. Twit Text FOAVip Exosomes and the Prion Protein: More than One Truth ????Front Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28469550 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28469550 #FOAvip English Wikipedia <ref>{{Cite pmid|28469550}}</ref> Exosomes and the Prion Protein: More than One Truth #MMPMID28469550 Hartmann A; Muth C; Dabrowski O; Krasemann S; Glatzel M Front Neurosci 2017[]; 11 (ä): ä PMID28469550show ga Exosomes are involved in the progression of neurodegenerative diseases. The cellular prion protein (PrPC) is highly expressed on exosomes. In neurodegenerative diseases, PrPC has at least two functions: It is the substrate for the generation of pathological prion protein (PrPSc), a key player in the pathophysiology of prion diseases. On the other hand, it binds neurotoxic amyloid-beta (Aß) oligomers, which are associated with initiation and progression of Alzheimer's disease (AD). This has direct consequences for the role of exosomal expressed PrPC. In prion diseases, exosomal PrP leads to efficient dissemination of pathological prion protein, thus promoting spreading and transmission of the disease. In AD, exosomal PrPC can bind and detoxify Aß oligomers thus acting protective. In both scenarios, assessment of the state of PrPC on exosomes derived from blood or cerebrospinal fluid (CSF) may be useful for diagnostic workup of these diseases. This review sums up current knowledge of the role of exosomal PrPC on different aspects of Alzheimer's and prion disease. äExosomes and the Prion Protein: More than One Truth (epmc).pdf DeepDyve Pubget Overpricing