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10.1038/ni.3706 http://scihub22266oqcxt.onion/10.1038/ni.3706 C5395420!5395420!28288100     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2017 ; 18 (5): 573-82 Nephropedia Template TP {{tp|p=28288100|t=2017. Epigenetic landscapes reveal transcription factors regulating CD8+ T cell differentiation |pdf=|usr=}}{{28288100}} gab.com Text Epigenetic landscapes reveal transcription factors regulating CD8+ T cell differentiation JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28288100 #FOAvip Dynamic changes in the expression of transcription factors (TFs) can influence specification of distinct CD8+ T cell fates, but the observation of equivalent expression of TF among differentially-fated precursor cells suggests additional underlying mechanisms. Here, we profiled genome-wide histone modifications, open chromatin and gene expression of naive, terminal-effector, memory-precursor and memory CD8+ T cell populations induced during the in vivo response to bacterial infection. Integration of these data suggested that TF expression and binding contributed to establishment of subset-specific enhancers during differentiation. We developed a new bioinformatics method using the PageRank algorithm to reveal novel TFs influencing the generation of effector and memory populations. The TFs YY1 and Nr3c1, both constitutively expressed during CD8+ T cell differentiation, regulated the formation of terminal-effector and memory-precursor cell-fates, respectively. Our data define the epigenetic landscape of differentiation intermediates, facilitating identification of TFs with previously unappreciated roles in CD8+ T cell differentiation. Twit Text FOAVip Epigenetic landscapes reveal transcription factors regulating CD8+ T cell differentiation ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28288100 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28288100 #FOAvip English Wikipedia <ref>{{Cite pmid|28288100}}</ref> Epigenetic landscapes reveal transcription factors regulating CD8+ T cell differentiation #MMPMID28288100 Yu B; Zhang K; Milner JJ; Toma C; Chen R; Scott-Browne JP; Pereira RM; Crotty S; Chang JT; Pipkin ME; Wang W; Goldrath AW Nat Immunol 2017[May]; 18 (5): 573-82 PMID28288100show ga Dynamic changes in the expression of transcription factors (TFs) can influence specification of distinct CD8+ T cell fates, but the observation of equivalent expression of TF among differentially-fated precursor cells suggests additional underlying mechanisms. Here, we profiled genome-wide histone modifications, open chromatin and gene expression of naive, terminal-effector, memory-precursor and memory CD8+ T cell populations induced during the in vivo response to bacterial infection. Integration of these data suggested that TF expression and binding contributed to establishment of subset-specific enhancers during differentiation. We developed a new bioinformatics method using the PageRank algorithm to reveal novel TFs influencing the generation of effector and memory populations. The TFs YY1 and Nr3c1, both constitutively expressed during CD8+ T cell differentiation, regulated the formation of terminal-effector and memory-precursor cell-fates, respectively. Our data define the epigenetic landscape of differentiation intermediates, facilitating identification of TFs with previously unappreciated roles in CD8+ T cell differentiation. äEpigenetic landscapes reveal transcription factors regulating CD8+ T c(epmc).pdf DeepDyve Pubget Overpricing