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10.7554/eLife.24176 http://scihub22266oqcxt.onion/10.7554/eLife.24176 C5395295!5395295!28418331     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28418331|t=2017. Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues |pdf=|usr=}}{{28418331}} gab.com Text Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28418331 #FOAvip The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching extant animal phyla, providing a unique opportunity to explore the evolutionary role of the cellular microenvironment in tissue genesis. Here, we characterized the extracellular matrix (ECM), with a focus on collagen IV and its variant, spongin short-chain collagens, of non-bilaterian animal phyla. We identified basement membrane (BM) and collagen IV in Ctenophora, and show that the structural and genomic features of collagen IV are homologous to those of non-bilaterian animal phyla and Bilateria. Yet, ctenophore features are more diverse and distinct, expressing up to twenty genes compared to six in vertebrates. Moreover, collagen IV is absent in unicellular sister-groups. Collectively, we conclude that collagen IV and its variant, spongin, are primordial components of the extracellular microenvironment, and as a component of BM, collagen IV enabled the assembly of a fundamental architectural unit for multicellular tissue genesis.DOI:http://dx.doi.org/10.7554/eLife.24176.001 Twit Text FOAVip Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28418331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28418331 #FOAvip English Wikipedia <ref>{{Cite pmid|28418331}}</ref> Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues #MMPMID28418331 Fidler AL; Darris CE; Chetyrkin SV; Pedchenko VK; Boudko SP; Brown KL; Gray Jerome W; Hudson JK; Rokas A; Hudson BG eLife 2017[]; 6 (ä): ä PMID28418331show ga The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching extant animal phyla, providing a unique opportunity to explore the evolutionary role of the cellular microenvironment in tissue genesis. Here, we characterized the extracellular matrix (ECM), with a focus on collagen IV and its variant, spongin short-chain collagens, of non-bilaterian animal phyla. We identified basement membrane (BM) and collagen IV in Ctenophora, and show that the structural and genomic features of collagen IV are homologous to those of non-bilaterian animal phyla and Bilateria. Yet, ctenophore features are more diverse and distinct, expressing up to twenty genes compared to six in vertebrates. Moreover, collagen IV is absent in unicellular sister-groups. Collectively, we conclude that collagen IV and its variant, spongin, are primordial components of the extracellular microenvironment, and as a component of BM, collagen IV enabled the assembly of a fundamental architectural unit for multicellular tissue genesis.DOI:http://dx.doi.org/10.7554/eLife.24176.001 äCollagen IV and basement membrane at the evolutionary dawn of metazoan(epmc).pdf DeepDyve Pubget Overpricing