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10.2147/DDDT.S110209

http://scihub22266oqcxt.onion/10.2147/DDDT.S110209
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C5395273!5395273!28442891
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suck abstract from ncbi


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pmid28442891      Drug+Des+Devel+Ther 2017 ; 11 (ä): 1175-82
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  • Spotlight on nivolumab in the treatment of renal cell carcinoma: design, development, and place in therapy #MMPMID28442891
  • Venur VA; Joshi M; Nepple KG; Zakharia Y
  • Drug Des Devel Ther 2017[]; 11 (ä): 1175-82 PMID28442891show ga
  • Several tyrosine kinase inhibitors targeting the vascular endothelial growth factor receptors and molecules inhibiting the mammalian target of rapamycin are being used for management of metastatic renal cell carcinoma (mRCC); however, there is still a potential for improvement. Immune checkpoint inhibitors like nivolumab and other PD-1/PD-L1 inhibitors provide an alternative approach for patients with mRCC. In this article, the authors review the safety profile and outcomes of phase 1, 2, and 3 clinical trials of nivolumab in mRCC.
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