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10.1242/jcs.185116 http://scihub22266oqcxt.onion/10.1242/jcs.185116 C5394774!5394774!26919978     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Sci 2017 ; 130 (1): 143-51 Nephropedia Template TP {{tp|p=26919978|t=2017. Cell polarity defines three distinct domains in pancreatic ?-cells |pdf=|usr=}}{{26919978}} gab.com Text Cell polarity defines three distinct domains in pancreatic -cells JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26919978 #FOAvip The structural organisation of pancreatic ?-cells in the islets of Langerhans is relatively unknown. Here, using three-dimensional (3D) two-photon, 3D confocal and 3D block-face serial electron microscopy, we demonstrate a consistent in situ polarisation of ?-cells and define three distinct cell surface domains. An apical domain located at the vascular apogee of ?-cells, defined by the location of PAR-3 (also known as PARD3) and ZO-1 (also known as TJP1), delineates an extracellular space into which adjacent ?-cells project their primary cilia. A separate lateral domain, is enriched in scribble and Dlg, and colocalises with E-cadherin and GLUT2 (also known as SLC2A2). Finally, a distinct basal domain, where the ?-cells contact the islet vasculature, is enriched in synaptic scaffold proteins such as liprin. This 3D analysis of ?-cells within intact islets, and the definition of distinct domains, provides new insights into understanding ?-cell structure and function. Twit Text FOAVip Cell polarity defines three distinct domains in pancreatic -cells ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26919978 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26919978 #FOAvip English Wikipedia <ref>{{Cite pmid|26919978}}</ref> Cell polarity defines three distinct domains in pancreatic ?-cells #MMPMID26919978 Gan WJ; Zavortink M; Ludick C; Templin R; Webb R; Webb R; Ma W; Poronnik P; Parton RG; Gaisano HY; Shewan AM; Thorn P J Cell Sci 2017[Jan]; 130 (1): 143-51 PMID26919978show ga The structural organisation of pancreatic ?-cells in the islets of Langerhans is relatively unknown. Here, using three-dimensional (3D) two-photon, 3D confocal and 3D block-face serial electron microscopy, we demonstrate a consistent in situ polarisation of ?-cells and define three distinct cell surface domains. An apical domain located at the vascular apogee of ?-cells, defined by the location of PAR-3 (also known as PARD3) and ZO-1 (also known as TJP1), delineates an extracellular space into which adjacent ?-cells project their primary cilia. A separate lateral domain, is enriched in scribble and Dlg, and colocalises with E-cadherin and GLUT2 (also known as SLC2A2). Finally, a distinct basal domain, where the ?-cells contact the islet vasculature, is enriched in synaptic scaffold proteins such as liprin. This 3D analysis of ?-cells within intact islets, and the definition of distinct domains, provides new insights into understanding ?-cell structure and function. äCell polarity defines three distinct domains in pancreatic ?-cells (epmc).pdf DeepDyve Pubget Overpricing