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10.1242/dev.138271 http://scihub22266oqcxt.onion/10.1242/dev.138271 C5394754!5394754!27993979     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Development 2017 ; 144 (2): 201-10 Nephropedia Template TP {{tp|p=27993979|t=2017. mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis |pdf=|usr=}}{{27993979}} gab.com Text mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis JO: Development http://www.kidney.de/pget.php?&tw=1&pmid=27993979 #FOAvip Radial glial cells (RCGs) are self-renewing progenitor cells that give rise to neurons and glia during embryonic development. Throughout neurogenesis, these cells contact the cerebral ventricles and bear a primary cilium. Although the role of the primary cilium in embryonic patterning has been studied, its role in brain ventricular morphogenesis is poorly characterized. Using conditional mutants, we show that the primary cilia of radial glia determine the size of the surface of their ventricular apical domain through regulation of the mTORC1 pathway. In cilium-less mutants, the orientation of the mitotic spindle in radial glia is also significantly perturbed and associated with an increased number of basal progenitors. The enlarged apical domain of RGCs leads to dilatation of the brain ventricles during late embryonic stages (ventriculomegaly), which initiates hydrocephalus during postnatal stages. These phenotypes can all be significantly rescued by treatment with the mTORC1 inhibitor rapamycin. These results suggest that primary cilia regulate ventricle morphogenesis by acting as a brake on the mTORC1 pathway. This opens new avenues for the diagnosis and treatment of hydrocephalus. Twit Text FOAVip mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis ????Development http://www.kidney.de/pget.php?&tw=1&pmid=27993979 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27993979 #FOAvip English Wikipedia <ref>{{Cite pmid|27993979}}</ref> mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis #MMPMID27993979 Foerster P; Daclin M; Asm S; Faucourt M; Boletta A; Genovesio A; Spassky N Development 2017[Jan]; 144 (2): 201-10 PMID27993979show ga Radial glial cells (RCGs) are self-renewing progenitor cells that give rise to neurons and glia during embryonic development. Throughout neurogenesis, these cells contact the cerebral ventricles and bear a primary cilium. Although the role of the primary cilium in embryonic patterning has been studied, its role in brain ventricular morphogenesis is poorly characterized. Using conditional mutants, we show that the primary cilia of radial glia determine the size of the surface of their ventricular apical domain through regulation of the mTORC1 pathway. In cilium-less mutants, the orientation of the mitotic spindle in radial glia is also significantly perturbed and associated with an increased number of basal progenitors. The enlarged apical domain of RGCs leads to dilatation of the brain ventricles during late embryonic stages (ventriculomegaly), which initiates hydrocephalus during postnatal stages. These phenotypes can all be significantly rescued by treatment with the mTORC1 inhibitor rapamycin. These results suggest that primary cilia regulate ventricle morphogenesis by acting as a brake on the mTORC1 pathway. This opens new avenues for the diagnosis and treatment of hydrocephalus. ämTORC1 signaling and primary cilia are required for brain ventricle mo(epmc).pdf DeepDyve Pubget Overpricing