The relationship between allergic status and adenotonsillar regrowth: a
retrospective research on children after adenotonsillectomy
#MMPMID28418014
Huo Z
; Shi J
; Shu Y
; Xiang M
; Lu J
; Wu H
Sci Rep
2017[Apr]; 7
(?): 46615
PMID28418014
show ga
Adenotonsillar regrowth in children after adenotonsillectomy (T&A) for
obstructive sleep apnea (OSA) is often seen in clinical treatment, however, the
relationship between allergic disease and adenotonsillar regrowth remains
unclear. In this retrospective study, children were assigned to either the
recurrence or control group, and subdivided by age at operation. Among children
over 36 months, those in the recurrence group had more allergic disease and
higher IgE, IL-4, and IL-5 levels than the same-aged children in control group.
The Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) scores for
nasal symptoms and activity were higher in children older than 36 months in
recurrence group. The results of immunohistochemistry and immunofluorescence
showed that FoxP3+ cells (Tregs) were less, while GATA3+ cells (Th2 cells) were
more in recurrence group for all ages. Allergic status and low levels of FoxP3
were proved as independent risk factors for adenotonsillar regrowth by
multivariate logistic regression. These results indicate that allergic disease is
a risk factor for adenotonsillar regrowth in children following T&A for OSA, and
this risk increases with age. The decreased level of Tregs and subsequent changes
in immune function play an important role in the pathogenesis of adenotonsillar
regrowth.
free
free
free
