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2017 ; 2017
(ä): 1292531
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English Wikipedia
In Acute IgA Nephropathy, Proteinuria and Creatinine Are in the Spot, but
Podocyturia Operates in Silence: Any Place for Amiloride?
#MMPMID28473934
Trimarchi H
; Paulero M
; Canzonieri R
; Schiel A
; Iotti A
; Costales-Collaguazo C
; Stern A
; Forrester M
; Lombi F
; Pomeranz V
; Iriarte R
; Rengel T
; Gonzalez-Hoyos I
; Muryan A
; Zotta E
Case Rep Nephrol
2017[]; 2017
(ä): 1292531
PMID28473934
show ga
IgA nephropathy is the most frequent cause of primary glomerulonephritis,
portends erratic patterns of clinical presentation, and lacks specific treatment.
In general, it slowly progresses to end-stage renal disease. The clinical course
and the response to therapy are usually assessed with proteinuria and serum
creatinine. Validated biomarkers have not been identified yet. In this report, we
present a case of acute renal injury with proteinuria and microscopic hematuria
in a young male. A kidney biopsy disclosed IgA nephropathy. Podocyturia was
significantly elevated compared to normal subjects. Proteinuria, renal function,
and podocyturia improved promptly after steroids and these variables remained
normal after one year of follow-up, when steroids had already been discontinued
and patient continued on valsartan and amiloride. Our report demonstrates that
podocyturia is critically elevated during an acute episode of IgA nephropathy,
and its occurrence may explain the grim long-term prognosis of this entity.
Whether podocyturia could be employed in IgA nephropathy as a trustable biomarker
for treatment assessment or even for early diagnosis of IgA nephropathy relapses
should be further investigated.
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