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10.1038/ncomms14923 http://scihub22266oqcxt.onion/10.1038/ncomms14923 C5394287!5394287 !28401884     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28401884 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 14923 Nephropedia Template TP {{tp|p=28401884 |t=2017. Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration |pdf=|usr=}}{{28401884 }} gab.com Text Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28401884 #FOAvip Directed migration by contact guidance is a poorly understood yet vital phenomenon, particularly for carcinoma cell invasion on aligned collagen fibres. We demonstrate that for single cells, aligned architectures providing contact guidance cues induce constrained focal adhesion maturation and associated F-actin alignment, consequently orchestrating anisotropic traction stresses that drive cell orientation and directional migration. Consistent with this understanding, relaxing spatial constraints to adhesion maturation either through reduction in substrate alignment density or reduction in adhesion size diminishes the contact guidance response. While such interactions allow single mesenchymal-like cells to spontaneously 'sense' and follow topographic alignment, intercellular interactions within epithelial clusters temper anisotropic cell-substratum forces, resulting in substantially lower directional response. Overall, these results point to the control of contact guidance by a balance of cell-substratum and cell-cell interactions, modulated by cell phenotype-specific cytoskeletal arrangements. Thus, our findings elucidate how phenotypically diverse cells perceive ECM alignment at the molecular level. Twit Text FOAVip Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28401884 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28401884 #FOAvip English Wikipedia <ref>{{Cite pmid|28401884 }}</ref> Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration #MMPMID28401884 Ray A ; Lee O ; Win Z ; Edwards RM ; Alford PW ; Kim DH ; Provenzano PP Nat Commun 2017[Apr]; 8 (ä): 14923 PMID28401884 show ga Directed migration by contact guidance is a poorly understood yet vital phenomenon, particularly for carcinoma cell invasion on aligned collagen fibres. We demonstrate that for single cells, aligned architectures providing contact guidance cues induce constrained focal adhesion maturation and associated F-actin alignment, consequently orchestrating anisotropic traction stresses that drive cell orientation and directional migration. Consistent with this understanding, relaxing spatial constraints to adhesion maturation either through reduction in substrate alignment density or reduction in adhesion size diminishes the contact guidance response. While such interactions allow single mesenchymal-like cells to spontaneously 'sense' and follow topographic alignment, intercellular interactions within epithelial clusters temper anisotropic cell-substratum forces, resulting in substantially lower directional response. Overall, these results point to the control of contact guidance by a balance of cell-substratum and cell-cell interactions, modulated by cell phenotype-specific cytoskeletal arrangements. Thus, our findings elucidate how phenotypically diverse cells perceive ECM alignment at the molecular level. |*Cell Communication [MESH] |*Cell Movement [MESH] |Actin Cytoskeleton/*metabolism [MESH] |Actins/metabolism [MESH] |Animals [MESH] |Anisotropy [MESH] |Cell Adhesion [MESH] |Cell Line, Tumor [MESH] |Focal Adhesions/*metabolism [MESH] |Humans [MESH] |Mice [MESH] |Microscopy, Confocal [MESH] |Neoplasms/metabolism/pathology [MESH]Anisotropic forces from spatially constrained focal adhesions mediate (epmc).pdf DeepDyve Pubget Overpricing