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10.1038/ncomms15000 http://scihub22266oqcxt.onion/10.1038/ncomms15000 C5394267!5394267 !28397831     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28397831 &cmd=llinks): Failed to open stream: HTTP request failed! 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MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-? signalling in osteoblasts |pdf=|usr=}}{{28397831 }} gab.com Text MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF- signalling in osteoblasts JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28397831 #FOAvip Osteocytes are the terminally differentiated cell type of the osteoblastic lineage and have important functions in skeletal homeostasis. Although the transcriptional regulation of osteoblast differentiation has been well characterized, the factors that regulate differentiation of osteocytes from mature osteoblasts are poorly understood. Here we show that miR-23a?27a?24-2 (miR-23a cluster) promotes osteocyte differentiation. Osteoblast-specific miR-23a cluster gain-of-function mice have low bone mass associated with decreased osteoblast but increased osteocyte numbers. By contrast, loss-of-function transgenic mice overexpressing microRNA decoys for either miR-23a or miR-27a, but not miR24-2, show decreased osteocyte numbers. Moreover, RNA-sequencing analysis shows altered transforming growth factor-? (TGF-?) signalling. Prdm16, a negative regulator of the TGF-? pathway, is directly repressed by miR-27a with concomitant alteration of sclerostin expression, and pharmacological inhibition of TGF-? rescues the phenotypes observed in the gain-of-function transgenic mice. Taken together, the miR-23a cluster regulates osteocyte differentiation by modulating the TGF-? signalling pathway through targeting of Prdm16. Twit Text FOAVip MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF- signalling in osteoblasts ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28397831 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28397831 #FOAvip English Wikipedia <ref>{{Cite pmid|28397831 }}</ref> MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-? signalling in osteoblasts #MMPMID28397831 Zeng HC ; Bae Y ; Dawson BC ; Chen Y ; Bertin T ; Munivez E ; Campeau PM ; Tao J ; Chen R ; Lee BH Nat Commun 2017[Apr]; 8 (ä): 15000 PMID28397831 show ga Osteocytes are the terminally differentiated cell type of the osteoblastic lineage and have important functions in skeletal homeostasis. Although the transcriptional regulation of osteoblast differentiation has been well characterized, the factors that regulate differentiation of osteocytes from mature osteoblasts are poorly understood. Here we show that miR-23a?27a?24-2 (miR-23a cluster) promotes osteocyte differentiation. Osteoblast-specific miR-23a cluster gain-of-function mice have low bone mass associated with decreased osteoblast but increased osteocyte numbers. By contrast, loss-of-function transgenic mice overexpressing microRNA decoys for either miR-23a or miR-27a, but not miR24-2, show decreased osteocyte numbers. Moreover, RNA-sequencing analysis shows altered transforming growth factor-? (TGF-?) signalling. Prdm16, a negative regulator of the TGF-? pathway, is directly repressed by miR-27a with concomitant alteration of sclerostin expression, and pharmacological inhibition of TGF-? rescues the phenotypes observed in the gain-of-function transgenic mice. Taken together, the miR-23a cluster regulates osteocyte differentiation by modulating the TGF-? signalling pathway through targeting of Prdm16. |*Gene Expression Regulation [MESH] |Animals [MESH] |Cell Differentiation/*genetics [MESH] |Cell Line [MESH] |Collagen Type I, alpha 1 Chain [MESH] |Collagen Type I/genetics/metabolism [MESH] |Female [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Mice, Transgenic [MESH] |MicroRNAs/*genetics [MESH] |Models, Genetic [MESH] |Multigene Family [MESH] |Osteocytes/cytology/*metabolism [MESH] |Osteogenesis/genetics [MESH] |Signal Transduction/*genetics [MESH]MicroRNA miR-23a cluster promotes osteocyte differentiation by regulat(epmc).pdf DeepDyve Pubget Overpricing