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10.1038/ncomms14960 http://scihub22266oqcxt.onion/10.1038/ncomms14960 C5394236!5394236!28393867     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28393867|t=2017. Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPAR? |pdf=|usr=}}{{28393867}} gab.com Text Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPAR JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28393867 #FOAvip Low-density lipoprotein receptor-related protein 1 (LRP1) regulates lipid and glucose metabolism in liver and adipose tissue. It is also involved in central nervous system regulation of food intake and leptin signalling. Here we demonstrate that endothelial Lrp1 regulates systemic energy homeostasis. Mice with endothelial-specific Lrp1 deletion display improved glucose sensitivity and lipid profiles combined with increased oxygen consumption during high-fat-diet-induced obesity. We show that the intracellular domain of Lrp1 interacts with the nuclear receptor Ppar?, a central regulator of lipid and glucose metabolism, acting as its transcriptional co-activator in endothelial cells. Therefore, Lrp1 not only acts as an endocytic receptor but also directly participates in gene transcription. Our findings indicate an underappreciated functional role of endothelium in maintaining systemic energy homeostasis. Twit Text FOAVip Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPAR ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28393867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28393867 #FOAvip English Wikipedia <ref>{{Cite pmid|28393867}}</ref> Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPAR? #MMPMID28393867 Mao H; Lockyer P; Li L; Ballantyne CM; Patterson C; Xie L; Pi X Nat Commun 2017[]; 8 (ä): ä PMID28393867show ga Low-density lipoprotein receptor-related protein 1 (LRP1) regulates lipid and glucose metabolism in liver and adipose tissue. It is also involved in central nervous system regulation of food intake and leptin signalling. Here we demonstrate that endothelial Lrp1 regulates systemic energy homeostasis. Mice with endothelial-specific Lrp1 deletion display improved glucose sensitivity and lipid profiles combined with increased oxygen consumption during high-fat-diet-induced obesity. We show that the intracellular domain of Lrp1 interacts with the nuclear receptor Ppar?, a central regulator of lipid and glucose metabolism, acting as its transcriptional co-activator in endothelial cells. Therefore, Lrp1 not only acts as an endocytic receptor but also directly participates in gene transcription. Our findings indicate an underappreciated functional role of endothelium in maintaining systemic energy homeostasis. äEndothelial LRP1 regulates metabolic responses by acting as a co-activ(epmc).pdf DeepDyve Pubget Overpricing