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10.1038/ncomms14807 http://scihub22266oqcxt.onion/10.1038/ncomms14807 C5394235!5394235 !28393874     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28393874 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 14807 Nephropedia Template TP {{tp|p=28393874 |t=2017. Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall |pdf=|usr=}}{{28393874 }} gab.com Text Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28393874 #FOAvip The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regulator of O(2)-dependent NO degradation in smooth muscle remains elusive. Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth muscle cells with unknown function. Cygb, coupled with a cellular reducing system, efficiently regulates the rate of NO consumption by metabolizing NO in an O(2)-dependent manner with decreased NO consumption in physiological hypoxia. Here we show that Cygb is a major regulator of NO degradation and cardiovascular tone. Knockout of Cygb greatly prolongs NO decay, increases vascular relaxation, and lowers blood pressure and systemic vascular resistance. We further demonstrate that downregulation of Cygb prevents angiotensin-mediated hypertension. Thus, Cygb has a critical role in the regulation of vascular tone and disease. We suggest that modulation of the expression and NOD activity of Cygb represents a strategy for the treatment of cardiovascular disease. Twit Text FOAVip Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28393874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28393874 #FOAvip English Wikipedia <ref>{{Cite pmid|28393874 }}</ref> Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall #MMPMID28393874 Liu X ; El-Mahdy MA ; Boslett J ; Varadharaj S ; Hemann C ; Abdelghany TM ; Ismail RS ; Little SC ; Zhou D ; Thuy LT ; Kawada N ; Zweier JL Nat Commun 2017[Apr]; 8 (ä): 14807 PMID28393874 show ga The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regulator of O(2)-dependent NO degradation in smooth muscle remains elusive. Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth muscle cells with unknown function. Cygb, coupled with a cellular reducing system, efficiently regulates the rate of NO consumption by metabolizing NO in an O(2)-dependent manner with decreased NO consumption in physiological hypoxia. Here we show that Cygb is a major regulator of NO degradation and cardiovascular tone. Knockout of Cygb greatly prolongs NO decay, increases vascular relaxation, and lowers blood pressure and systemic vascular resistance. We further demonstrate that downregulation of Cygb prevents angiotensin-mediated hypertension. Thus, Cygb has a critical role in the regulation of vascular tone and disease. We suggest that modulation of the expression and NOD activity of Cygb represents a strategy for the treatment of cardiovascular disease. |Animals [MESH] |Blood Pressure/*physiology [MESH] |Cardiovascular Diseases/prevention & control [MESH] |Cells, Cultured [MESH] |Cyclic GMP/metabolism [MESH] |Cytoglobin/genetics/*physiology [MESH] |Down-Regulation [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |Male [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Muscle Tonus/*physiology [MESH] |Muscle, Smooth, Vascular/enzymology/metabolism/*physiology [MESH] |Nitric Oxide Synthase Type III/metabolism [MESH] |Nitric Oxide/*metabolism [MESH] |Oxygenases/metabolism [MESH] |Rats [MESH] |Tunica Intima/enzymology/metabolism/*physiology [MESH] |Vascular Resistance/physiology [MESH]Cytoglobin regulates blood pressure and vascular tone through nitric o(epmc).pdf DeepDyve Pubget Overpricing