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10.1073/pnas.1617290114 http://scihub22266oqcxt.onion/10.1073/pnas.1617290114 C5393238!5393238!28356517     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (15): 3963-8 Nephropedia Template TP {{tp|p=28356517|t=2017. Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection |pdf=|usr=}}{{28356517}} gab.com Text Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28356517 #FOAvip We provide evidence for a functional role of bioactive lipid mediators of the docosapentaenoic acid (DPA) metabolome in intestinal inflammation. Supported by changes in DPA-derived mediators in colon biopsies from inflammatory bowel diseases, we studied the pharmacological properties of two mediators. Exogenous administration of protectin (PD)1n-3 DPA or resolvin (Rv)D5n-3 DPA in mice reduced dextran sulfate sodium-induced colitis though a mechanism partly linked to decreased leukocyte?endothelial interaction and reduced granulocyte trafficking, as assessed by intravital microscopy. The translational impact of these data was determined by the ability of PD1n-3 DPA and RvD5n-3 DPA to reduce human neutrophil adhesion onto TNF-??activated human endothelial monolayers. We propose that n-3 DPA-derived mediators could represent the basis for innovative therapeutic strategies in settings of intestinal inflammation. Twit Text FOAVip Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28356517 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28356517 #FOAvip English Wikipedia <ref>{{Cite pmid|28356517}}</ref> Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection #MMPMID28356517 Gobbetti T; Dalli J; Colas RA; Federici Canova D; Aursnes M; Bonnet D; Alric L; Vergnolle N; Deraison C; Hansen TV; Serhan CN; Perretti M Proc Natl Acad Sci U S A 2017[Apr]; 114 (15): 3963-8 PMID28356517show ga We provide evidence for a functional role of bioactive lipid mediators of the docosapentaenoic acid (DPA) metabolome in intestinal inflammation. Supported by changes in DPA-derived mediators in colon biopsies from inflammatory bowel diseases, we studied the pharmacological properties of two mediators. Exogenous administration of protectin (PD)1n-3 DPA or resolvin (Rv)D5n-3 DPA in mice reduced dextran sulfate sodium-induced colitis though a mechanism partly linked to decreased leukocyte?endothelial interaction and reduced granulocyte trafficking, as assessed by intravital microscopy. The translational impact of these data was determined by the ability of PD1n-3 DPA and RvD5n-3 DPA to reduce human neutrophil adhesion onto TNF-??activated human endothelial monolayers. We propose that n-3 DPA-derived mediators could represent the basis for innovative therapeutic strategies in settings of intestinal inflammation. äProtectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal(epmc).pdf DeepDyve Pubget Overpricing