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10.1101/gad.297002.117 http://scihub22266oqcxt.onion/10.1101/gad.297002.117 C5393059!5393059 !28385788     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28385788 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2017 ; 31 (5 ): 439-450 Nephropedia Template TP {{tp|p=28385788 |t=2017. The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma |pdf=|usr=}}{{28385788 }} gab.com Text The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=28385788 #FOAvip Lymphocyte differentiation is set to produce myriad immune effector cells with the ability to respond to multitudinous foreign substances. The uniqueness of this developmental system lies in not only the great diversity of cellular functions that it can generate but also the ability of its differentiation intermediates and mature effector cells to expand upon demand, thereby providing lifelong immunity. Surprisingly, the goals of this developmental system are met by a relatively small group of DNA-binding transcription factors that work in concert to control the timing and magnitude of gene expression and fulfill the demands for cellular specialization, expansion, and maintenance. The cellular and molecular mechanisms through which these lineage-promoting transcription factors operate have been a focus of basic research in immunology. The mechanisms of development discerned in this effort are guiding clinical research on disorders with an immune cell base. Here, I focus on IKAROS, one of the earliest regulators of lymphoid lineage identity and a guardian of lymphocyte homeostasis. Twit Text FOAVip The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=28385788 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28385788 #FOAvip English Wikipedia <ref>{{Cite pmid|28385788 }}</ref> The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma #MMPMID28385788 Georgopoulos K Genes Dev 2017[Mar]; 31 (5 ): 439-450 PMID28385788 show ga Lymphocyte differentiation is set to produce myriad immune effector cells with the ability to respond to multitudinous foreign substances. The uniqueness of this developmental system lies in not only the great diversity of cellular functions that it can generate but also the ability of its differentiation intermediates and mature effector cells to expand upon demand, thereby providing lifelong immunity. Surprisingly, the goals of this developmental system are met by a relatively small group of DNA-binding transcription factors that work in concert to control the timing and magnitude of gene expression and fulfill the demands for cellular specialization, expansion, and maintenance. The cellular and molecular mechanisms through which these lineage-promoting transcription factors operate have been a focus of basic research in immunology. The mechanisms of development discerned in this effort are guiding clinical research on disorders with an immune cell base. Here, I focus on IKAROS, one of the earliest regulators of lymphoid lineage identity and a guardian of lymphocyte homeostasis. |Animals [MESH] |Cell Differentiation/*genetics/*immunology [MESH] |Cell Lineage/genetics/immunology [MESH] |Gene Expression Regulation, Developmental [MESH] |Homeostasis/genetics/immunology [MESH] |Humans [MESH] |Ikaros Transcription Factor/*genetics/immunology [MESH] |Lymphocytes/*cytology/*immunology [MESH]The making of a lymphocyte: the choice among disparate cell fates and (epmc).pdf DeepDyve Pubget Overpricing