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10.1101/gad.292870.116

http://scihub22266oqcxt.onion/10.1101/gad.292870.116
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C5393054!5393054!28381411
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suck abstract from ncbi


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pmid28381411      Genes+Dev 2017 ; 31 (6): 590-602
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  • Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements #MMPMID28381411
  • Erceg J; Pakozdi T; Marco-Ferreres R; Ghavi-Helm Y; Girardot C; Bracken AP; Furlong EE
  • Genes Dev 2017[Mar]; 31 (6): 590-602 PMID28381411show ga
  • Here, Erceg et al. studied the occupancy of the Drosophila PhoRC during embryogenesis and revealed extensive co-occupancy at developmental enhancers. By using an established in vivo assay for Polycomb response element (PRE) activity, they show that a subset of characterized developmental enhancers can function as PREs and silence transcription in a Polycomb-dependent manner, thereby suggesting that reuse of the same elements by the PcG system may help fine-tune gene expression and ensure the timely maintenance of cell identities.
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