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10.1101/gad.292318.116

http://scihub22266oqcxt.onion/10.1101/gad.292318.116
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C5393051!5393051!28404630
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suck abstract from ncbi


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pmid28404630      Genes+Dev 2017 ; 31 (6): 553-66
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  • miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy #MMPMID28404630
  • Rodriguez-Barrueco R; Nekritz EA; Bertucci F; Yu J; Sanchez-Garcia F; Zeleke TZ; Gorbatenko A; Birnbaum D; Ezhkova E; Cordon-Cardo C; Finetti P; Llobet-Navas D; Silva JM
  • Genes Dev 2017[Mar]; 31 (6): 553-66 PMID28404630show ga
  • In this study, Rodriguez-Barrueco et al. analyzed ?3000 primary tumors and show that miR-424(322)/503 is commonly lost in a subset of aggressive breast cancers; they then describe the genetic aberrations that inactivate its expression. Their data show that miR-424(322)/503 is a tumor suppressor in breast cancer and provide a link between mammary epithelial involution, tumorigenesis, and the phenomenon of chemoresistance.
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