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10.1101/gad.292318.116 http://scihub22266oqcxt.onion/10.1101/gad.292318.116 C5393051!5393051 !28404630     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28404630 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2017 ; 31 (6 ): 553-566 Nephropedia Template TP {{tp|p=28404630 |t=2017. miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy |pdf=|usr=}}{{28404630 }} gab.com Text miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=28404630 #FOAvip The female mammary gland is a very dynamic organ that undergoes continuous tissue remodeling during adulthood. Although it is well established that the number of menstrual cycles and pregnancy (in this case transiently) increase the risk of breast cancer, the reasons are unclear. Growing clinical and experimental evidence indicates that improper involution plays a role in the development of this malignancy. Recently, we described the miR-424(322)/503 cluster as an important regulator of mammary epithelial involution after pregnancy. Here, through the analysis of ?3000 primary tumors, we show that miR-424(322)/503 is commonly lost in a subset of aggressive breast cancers and describe the genetic aberrations that inactivate its expression. Furthermore, through the use of a knockout mouse model, we demonstrate for the first time that loss of miR-424(322)/503 promotes breast tumorigenesis in vivo. Remarkably, we found that loss of miR-424(322)/503 promotes chemoresistance due to the up-regulation of two of its targets: BCL-2 and insulin-like growth factor-1 receptor (IGF1R). Importantly, targeted therapies blocking the aberrant activity of these targets restore sensitivity to chemotherapy. Overall, our studies reveal miR-424(322)/503 as a tumor suppressor in breast cancer and provide a link between mammary epithelial involution, tumorigenesis, and the phenomenon of chemoresistance. Twit Text FOAVip miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=28404630 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28404630 #FOAvip English Wikipedia <ref>{{Cite pmid|28404630 }}</ref> miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy #MMPMID28404630 Rodriguez-Barrueco R ; Nekritz EA ; Bertucci F ; Yu J ; Sanchez-Garcia F ; Zeleke TZ ; Gorbatenko A ; Birnbaum D ; Ezhkova E ; Cordon-Cardo C ; Finetti P ; Llobet-Navas D ; Silva JM Genes Dev 2017[Mar]; 31 (6 ): 553-566 PMID28404630 show ga The female mammary gland is a very dynamic organ that undergoes continuous tissue remodeling during adulthood. Although it is well established that the number of menstrual cycles and pregnancy (in this case transiently) increase the risk of breast cancer, the reasons are unclear. Growing clinical and experimental evidence indicates that improper involution plays a role in the development of this malignancy. Recently, we described the miR-424(322)/503 cluster as an important regulator of mammary epithelial involution after pregnancy. Here, through the analysis of ?3000 primary tumors, we show that miR-424(322)/503 is commonly lost in a subset of aggressive breast cancers and describe the genetic aberrations that inactivate its expression. Furthermore, through the use of a knockout mouse model, we demonstrate for the first time that loss of miR-424(322)/503 promotes breast tumorigenesis in vivo. Remarkably, we found that loss of miR-424(322)/503 promotes chemoresistance due to the up-regulation of two of its targets: BCL-2 and insulin-like growth factor-1 receptor (IGF1R). Importantly, targeted therapies blocking the aberrant activity of these targets restore sensitivity to chemotherapy. Overall, our studies reveal miR-424(322)/503 as a tumor suppressor in breast cancer and provide a link between mammary epithelial involution, tumorigenesis, and the phenomenon of chemoresistance. |Animals [MESH] |Breast Neoplasms/drug therapy/*genetics/mortality [MESH] |Cell Line, Tumor [MESH] |Drug Resistance, Neoplasm [MESH] |Female [MESH] |Gene Deletion [MESH] |Genes, Tumor Suppressor [MESH] |Humans [MESH] |Mammary Neoplasms, Experimental/genetics [MESH] |Mice [MESH] |MicroRNAs/*genetics [MESH] |Pregnancy [MESH] |Pregnancy Complications, Neoplastic/genetics [MESH] |Proto-Oncogene Proteins c-bcl-2/genetics [MESH] |Receptor, IGF Type 1 [MESH] |Receptors, Somatomedin/genetics [MESH]miR-424(322)/503 is a breast cancer tumor suppressor whose loss promot(epmc).pdf DeepDyve Pubget Overpricing