Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s13578-017-0143-9 http://scihub22266oqcxt.onion/10.1186/s13578-017-0143-9 C5392960!5392960!28428837     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Biosci 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28428837|t=2017. Large is required for normal astrocyte migration and retinal vasculature development |pdf=|usr=}}{{28428837}} gab.com Text Large is required for normal astrocyte migration and retinal vasculature development JO: Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=28428837 #FOAvip Background: Persistent fetal vasculature (PFV) is a congenital developmental anomaly of the eye that accounts for about 5% of childhood blindness. The molecular mechanism of PFV remains unclear. As a glycosyltransferase of ?-dystroglycan, LARGE mutations have been found in congenital muscular dystrophy patients with brain abnormalities. Spontaneous Large mutant mice displayed similar symptoms of human muscle?eye?brain disorders. However, the detailed roles of Large in ocular vasculature development still need to be uncovered. Results: In this paper, we report that a novel Large mutation generated by the piggyBac transposon insertion leads to PFV and abnormal retinal vasculature in mice. Glycosylation of ?-DG, an essential component of the extracellular matrix, was significantly impaired in these Large mutants, leading to broken inner limiting membrane (ILM). As a guide of the retinal vasculature development, the distribution of retinal astrocytes became irregular within the retina, and many astrocytes abnormally migrated into the vitreous along with the hyaloid vessels in Large mutants. Conclusions: Large is essential for ILM formation and retinal astrocyte migration. The novel Large mutant mouse can serve as a new PFV model to further dissect LARGE functions in ocular vasculature development. Twit Text FOAVip Large is required for normal astrocyte migration and retinal vasculature development ????Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=28428837 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28428837 #FOAvip English Wikipedia <ref>{{Cite pmid|28428837}}</ref> Large is required for normal astrocyte migration and retinal vasculature development #MMPMID28428837 Zhou M; Wang H; Ren H; Jiang R; Zhang C; Wu X; Xu G Cell Biosci 2017[]; 7 (ä): ä PMID28428837show ga Background: Persistent fetal vasculature (PFV) is a congenital developmental anomaly of the eye that accounts for about 5% of childhood blindness. The molecular mechanism of PFV remains unclear. As a glycosyltransferase of ?-dystroglycan, LARGE mutations have been found in congenital muscular dystrophy patients with brain abnormalities. Spontaneous Large mutant mice displayed similar symptoms of human muscle?eye?brain disorders. However, the detailed roles of Large in ocular vasculature development still need to be uncovered. Results: In this paper, we report that a novel Large mutation generated by the piggyBac transposon insertion leads to PFV and abnormal retinal vasculature in mice. Glycosylation of ?-DG, an essential component of the extracellular matrix, was significantly impaired in these Large mutants, leading to broken inner limiting membrane (ILM). As a guide of the retinal vasculature development, the distribution of retinal astrocytes became irregular within the retina, and many astrocytes abnormally migrated into the vitreous along with the hyaloid vessels in Large mutants. Conclusions: Large is essential for ILM formation and retinal astrocyte migration. The novel Large mutant mouse can serve as a new PFV model to further dissect LARGE functions in ocular vasculature development. äLarge is required for normal astrocyte migration and retinal vasculatu(epmc).pdf DeepDyve Pubget Overpricing