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10.1074/jbc.M116.769141 http://scihub22266oqcxt.onion/10.1074/jbc.M116.769141 C5392672!5392672 !28193839     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28193839 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2017 ; 292 (13 ): 5253-5261 Nephropedia Template TP {{tp|p=28193839 |t=2017. Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ?Np63? Protein Expression and Inhibits Cancer Cell Viability |pdf=|usr=}}{{28193839 }} gab.com Text Metformin Promotes AMP-activated Protein Kinase-independent Suppression of Np63 Protein Expression and Inhibits Cancer Cell Viability JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28193839 #FOAvip The blood glucose modifier metformin is used to treat type II diabetes and has also been shown to possess anticancer activities. Recent studies indicate that glucose deprivation can greatly enhance metformin-mediated inhibition of cell viability, but the molecular mechanism involved in this inhibition is unclear. In this study, we report that, under glucose deprivation, metformin inhibited expression of ?Np63?, a p53 family member involved in cell adhesion pathways, resulting in disruption of cell matrix adhesion and subsequent apoptosis in human squamous carcinoma cells. We further show that metformin promoted ?Np63? protein instability independent of AMP-activated protein kinase and that WWP1, an E3 ligase of ?Np63?, was involved in metformin-mediated down-regulation of ?Np63? levels. In addition, we demonstrate that a combination of metformin and the glycolysis inhibitor 2-deoxy-d-glucose significantly inhibited ?Np63? expression and also suppressed xenographic tumor growth in vivo In summary, this study reveals a new mechanism for metformin-mediated anticancer activity and suggests a new strategy for treating human squamous cell carcinoma. Twit Text FOAVip Metformin Promotes AMP-activated Protein Kinase-independent Suppression of Np63 Protein Expression and Inhibits Cancer Cell Viability ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28193839 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28193839 #FOAvip English Wikipedia <ref>{{Cite pmid|28193839 }}</ref> Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ?Np63? Protein Expression and Inhibits Cancer Cell Viability #MMPMID28193839 Yi Y ; Chen D ; Ao J ; Sun S ; Wu M ; Li X ; Bergholz J ; Zhang Y ; Xiao ZX J Biol Chem 2017[Mar]; 292 (13 ): 5253-5261 PMID28193839 show ga The blood glucose modifier metformin is used to treat type II diabetes and has also been shown to possess anticancer activities. Recent studies indicate that glucose deprivation can greatly enhance metformin-mediated inhibition of cell viability, but the molecular mechanism involved in this inhibition is unclear. In this study, we report that, under glucose deprivation, metformin inhibited expression of ?Np63?, a p53 family member involved in cell adhesion pathways, resulting in disruption of cell matrix adhesion and subsequent apoptosis in human squamous carcinoma cells. We further show that metformin promoted ?Np63? protein instability independent of AMP-activated protein kinase and that WWP1, an E3 ligase of ?Np63?, was involved in metformin-mediated down-regulation of ?Np63? levels. In addition, we demonstrate that a combination of metformin and the glycolysis inhibitor 2-deoxy-d-glucose significantly inhibited ?Np63? expression and also suppressed xenographic tumor growth in vivo In summary, this study reveals a new mechanism for metformin-mediated anticancer activity and suggests a new strategy for treating human squamous cell carcinoma. |AMP-Activated Protein Kinases [MESH] |Animals [MESH] |Antineoplastic Agents/pharmacology [MESH] |Carcinoma, Squamous Cell/*drug therapy/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Survival/drug effects [MESH] |Deoxyglucose/pharmacology [MESH] |Drug Therapy, Combination [MESH] |Heterografts [MESH] |Humans [MESH] |Metformin/*pharmacology/therapeutic use [MESH] |Mice [MESH] |Protein Stability/drug effects [MESH] |Transcription Factors/*antagonists & inhibitors [MESH]Metformin Promotes AMP-activated Protein Kinase-independent Suppressio(epmc).pdf DeepDyve Pubget Overpricing