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10.1074/jbc.M116.771451 http://scihub22266oqcxt.onion/10.1074/jbc.M116.771451 C5392569!5392569 !28196862     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28196862 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28196862 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2017 ; 292 (14 ): 5737-5747 Nephropedia Template TP {{tp|p=28196862 |t=2017. mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery |pdf=|usr=}}{{28196862 }} gab.com Text mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28196862 #FOAvip The plasma membrane of mammalian cells undergoes constitutive endocytosis, endocytic sorting, and recycling, which delivers nutrients to the lysosomes. The receptors, along with membrane lipids, are normally returned to the plasma membrane to sustain this action. It is not known, however, whether this process is influenced by metabolic conditions. Here we report that endocytic recycling requires active mechanistic target of rapamycin (aka mammalian target of rapamycin) (mTORC1), a master metabolic sensor. Upon mTORC1 inactivation, either by starvation or by inhibitor, recycling receptors and plasma membrane lipids, such as transferrin receptors and sphingomyelin, are delivered to the lysosomes. This lysosomal targeting is independent of canonical autophagy: both WT and Atg5(-/-) mouse embryonic fibroblasts responded similarly. Furthermore, we identify hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs), an endosomal sorting complexes required for transport (ESCORT-0) component, as a downstream target of mTORC1. Hrs requires mTORC1 activity to maintain its protein expression level. Silencing Hrs without decreasing mTORC1 activity is sufficient to target transferrin and sphingomyelin to the lysosomes. It is thus evident that the canonical recycling pathway is under the regulation of mTORC1 and likely most predominant in proliferating cells where mTORC1 is highly active. Twit Text FOAVip mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28196862 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28196862 #FOAvip English Wikipedia <ref>{{Cite pmid|28196862 }}</ref> mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery #MMPMID28196862 Dauner K ; Eid W ; Raghupathy R ; Presley JF ; Zha X J Biol Chem 2017[Apr]; 292 (14 ): 5737-5747 PMID28196862 show ga The plasma membrane of mammalian cells undergoes constitutive endocytosis, endocytic sorting, and recycling, which delivers nutrients to the lysosomes. The receptors, along with membrane lipids, are normally returned to the plasma membrane to sustain this action. It is not known, however, whether this process is influenced by metabolic conditions. Here we report that endocytic recycling requires active mechanistic target of rapamycin (aka mammalian target of rapamycin) (mTORC1), a master metabolic sensor. Upon mTORC1 inactivation, either by starvation or by inhibitor, recycling receptors and plasma membrane lipids, such as transferrin receptors and sphingomyelin, are delivered to the lysosomes. This lysosomal targeting is independent of canonical autophagy: both WT and Atg5(-/-) mouse embryonic fibroblasts responded similarly. Furthermore, we identify hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs), an endosomal sorting complexes required for transport (ESCORT-0) component, as a downstream target of mTORC1. Hrs requires mTORC1 activity to maintain its protein expression level. Silencing Hrs without decreasing mTORC1 activity is sufficient to target transferrin and sphingomyelin to the lysosomes. It is thus evident that the canonical recycling pathway is under the regulation of mTORC1 and likely most predominant in proliferating cells where mTORC1 is highly active. |Animals [MESH] |Autophagy-Related Protein 5/genetics/metabolism [MESH] |Biological Transport, Active/physiology [MESH] |Cell Proliferation/physiology [MESH] |Cells, Cultured [MESH] |Embryo, Mammalian/cytology/*metabolism [MESH] |Endocytosis/*physiology [MESH] |Endosomal Sorting Complexes Required for Transport/genetics/metabolism [MESH] |Fibroblasts/cytology/*metabolism [MESH] |Lysosomes/genetics/*metabolism [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Multiprotein Complexes/genetics/*metabolism [MESH] |Sphingomyelins/genetics/*metabolism [MESH] |TOR Serine-Threonine Kinases/genetics/*metabolism [MESH]mTOR complex 1 activity is required to maintain the canonical endocyti(epmc).pdf DeepDyve Pubget Overpricing