Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28416952
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Tuberc+Respir+Dis+(Seoul)
2017 ; 80
(2
): 113-135
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity
and Phenotypes of Asthma
#MMPMID28416952
Rolfes MC
; Juhn YJ
; Wi CI
; Sheen YH
Tuberc Respir Dis (Seoul)
2017[Apr]; 80
(2
): 113-135
PMID28416952
show ga
Asthma is traditionally regarded as a chronic airway disease, and recent
literature proves its heterogeneity, based on distinctive clusters or phenotypes
of asthma. In defining such asthma clusters, the nature of comorbidity among
patients with asthma is poorly understood, by assuming no causal relationship
between asthma and other comorbid conditions, including both communicable and
noncommunicable diseases. However, emerging evidence suggests that the status of
asthma significantly affects the increased susceptibility of the patient to both
communicable and noncommunicable diseases. Specifically, the impact of asthma on
susceptibility to noncommunicable diseases such as chronic systemic inflammatory
diseases (e.g., rheumatoid arthritis), may provide an important insight into
asthma as a disease with systemic inflammatory features, a conceptual
understanding between asthma and asthma-related comorbidity, and the potential
implications on the therapeutic and preventive interventions for patients with
asthma. This review discusses the currently under-recognized clinical and
immunological phenotypes of asthma; specifically, a higher risk of developing a
systemic inflammatory disease such as rheumatoid arthritis and their
implications, on the conceptual understanding and management of asthma. Our
discussion is divided into three parts: literature summary on the relationship
between asthma and the risk of rheumatoid arthritis; potential mechanisms
underlying the association; and implications on asthma management and research.