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10.1158/1078-0432.CCR-15-2240 http://scihub22266oqcxt.onion/10.1158/1078-0432.CCR-15-2240 C5392367!5392367!28053024     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Cancer+Res 2017 ; 23 (8): 1891-7 Nephropedia Template TP {{tp|p=28053024|t=2017. Molecular Pathways: Revisiting Glycogen Synthase Kinase-3? as a target for the treatment of cancer |pdf=|usr=}}{{28053024}} gab.com Text Molecular Pathways: Revisiting Glycogen Synthase Kinase-3 as a target for the treatment of cancer JO: Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28053024 #FOAvip Glycogen synthase kinase-3? (GSK-3?), a serine/threonine protein kinase, is a complex regulator of numerous cellular functions. GSK-3? is a unique kinase which is constitutively active in resting and non-stimulated cells. GSK-3? has been implicated in a wide range of diseases including neurodegeneration, inflammation and fibrosis, noninsulin-dependent diabetes mellitus, and cancer. It is a regulator of NF-?B-mediated survival of cancer cells, which provided a rationale for the development of GSK-3 inhibitors targeting malignant tumors. Recent studies, many of them reported over the past decade, have identified GSK-3? as a potential therapeutic target in at over 15 different types of cancer. Whereas only active GSK-3? is expressed in cancer cell nucleus, aberrant nuclear accumulation of GSK-3? has been identified as a hallmark of cancer cells in malignant tumors of different origin. This review focuses on the preclinical and clinical development of GSK-3 inhibitors, and the potential therapeutic impact of targeting GSK-3? in human cancer. Twit Text FOAVip Molecular Pathways: Revisiting Glycogen Synthase Kinase-3 as a target for the treatment of cancer ????Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28053024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28053024 #FOAvip English Wikipedia <ref>{{Cite pmid|28053024}}</ref> Molecular Pathways: Revisiting Glycogen Synthase Kinase-3? as a target for the treatment of cancer #MMPMID28053024 Walz A; Ugolkov A; Chandra S; Kozikowski A; Carneiro BA; O?Halloran TV; Giles FJ; Billadeau DD; Mazar AP Clin Cancer Res 2017[Apr]; 23 (8): 1891-7 PMID28053024show ga Glycogen synthase kinase-3? (GSK-3?), a serine/threonine protein kinase, is a complex regulator of numerous cellular functions. GSK-3? is a unique kinase which is constitutively active in resting and non-stimulated cells. GSK-3? has been implicated in a wide range of diseases including neurodegeneration, inflammation and fibrosis, noninsulin-dependent diabetes mellitus, and cancer. It is a regulator of NF-?B-mediated survival of cancer cells, which provided a rationale for the development of GSK-3 inhibitors targeting malignant tumors. Recent studies, many of them reported over the past decade, have identified GSK-3? as a potential therapeutic target in at over 15 different types of cancer. Whereas only active GSK-3? is expressed in cancer cell nucleus, aberrant nuclear accumulation of GSK-3? has been identified as a hallmark of cancer cells in malignant tumors of different origin. This review focuses on the preclinical and clinical development of GSK-3 inhibitors, and the potential therapeutic impact of targeting GSK-3? in human cancer. äMolecular Pathways: Revisiting Glycogen Synthase Kinase-3? as a target(epmc).pdf DeepDyve Pubget Overpricing