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10.1158/1078-0432.CCR-15-2240 http://scihub22266oqcxt.onion/10.1158/1078-0432.CCR-15-2240 C5392367!5392367 !28053024     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28053024 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Cancer+Res 2017 ; 23 (8 ): 1891-1897 Nephropedia Template TP {{tp|p=28053024 |t=2017. Molecular Pathways: Revisiting Glycogen Synthase Kinase-3? as a Target for the Treatment of Cancer |pdf=|usr=}}{{28053024 }} gab.com Text Molecular Pathways: Revisiting Glycogen Synthase Kinase-3 as a Target for the Treatment of Cancer JO: Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28053024 #FOAvip Glycogen synthase kinase-3? (GSK-3?), a serine/threonine protein kinase, is a complex regulator of numerous cellular functions. GSK-3? is a unique kinase which is constitutively active in resting and nonstimulated cells. GSK-3? has been implicated in a wide range of diseases including neurodegeneration, inflammation and fibrosis, noninsulin-dependent diabetes mellitus, and cancer. It is a regulator of NF-?B-mediated survival of cancer cells, which provided a rationale for the development of GSK-3 inhibitors targeting malignant tumors. Recent studies, many of them reported over the past decade, have identified GSK-3? as a potential therapeutic target in more than 15 different types of cancer. Whereas only active GSK-3? is expressed in cancer cell nucleus, aberrant nuclear accumulation of GSK-3? has been identified as a hallmark of cancer cells in malignant tumors of different origin. This review focuses on the preclinical and clinical development of GSK-3 inhibitors and the potential therapeutic impact of targeting GSK-3? in human cancer. Clin Cancer Res; 23(8); 1891-7. ©2017 AACR. Twit Text FOAVip Molecular Pathways: Revisiting Glycogen Synthase Kinase-3 as a Target for the Treatment of Cancer ????Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28053024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28053024 #FOAvip English Wikipedia <ref>{{Cite pmid|28053024 }}</ref> Molecular Pathways: Revisiting Glycogen Synthase Kinase-3? as a Target for the Treatment of Cancer #MMPMID28053024 Walz A ; Ugolkov A ; Chandra S ; Kozikowski A ; Carneiro BA ; O'Halloran TV ; Giles FJ ; Billadeau DD ; Mazar AP Clin Cancer Res 2017[Apr]; 23 (8 ): 1891-1897 PMID28053024 show ga Glycogen synthase kinase-3? (GSK-3?), a serine/threonine protein kinase, is a complex regulator of numerous cellular functions. GSK-3? is a unique kinase which is constitutively active in resting and nonstimulated cells. GSK-3? has been implicated in a wide range of diseases including neurodegeneration, inflammation and fibrosis, noninsulin-dependent diabetes mellitus, and cancer. It is a regulator of NF-?B-mediated survival of cancer cells, which provided a rationale for the development of GSK-3 inhibitors targeting malignant tumors. Recent studies, many of them reported over the past decade, have identified GSK-3? as a potential therapeutic target in more than 15 different types of cancer. Whereas only active GSK-3? is expressed in cancer cell nucleus, aberrant nuclear accumulation of GSK-3? has been identified as a hallmark of cancer cells in malignant tumors of different origin. This review focuses on the preclinical and clinical development of GSK-3 inhibitors and the potential therapeutic impact of targeting GSK-3? in human cancer. Clin Cancer Res; 23(8); 1891-7. ©2017 AACR. |Animals [MESH] |Antineoplastic Agents/pharmacology [MESH] |Glycogen Synthase Kinase 3 beta/*antagonists & inhibitors [MESH] |Humans [MESH] |Molecular Targeted Therapy/*methods [MESH] |Neoplasms/drug therapy/*enzymology [MESH]Molecular Pathways: Revisiting Glycogen Synthase Kinase-3? as a Target(epmc).pdf DeepDyve Pubget Overpricing