Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28209917
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Artesunate suppresses the viability and mobility of prostate cancer cells through
UCA1, the sponge of miR-184
#MMPMID28209917
Zhou Y
; Wang X
; Zhang J
; He A
; Wang YL
; Han K
; Su Y
; Yin J
; Lv X
; Hu H
Oncotarget
2017[Mar]; 8
(11
): 18260-18270
PMID28209917
show ga
Artesunate (ART) is a sesquiterpene lactone isolated from the leafy portions of
the Chinese herb Artemisia annua. Here, we evaluated the effect of ART on the
prostate cancer (PCa) cell lines DU145 and LNCaP and explored its potential
mechanisms. ART inhibited the viability and mobility of DU145 and LNCaP cells.
Mechanistically, we found that UCA1, one of the most important lncRNAs in
malignancies of the urinary system, may be a potential mediator contributing to
the tumor suppressor function of ART. First, the UCA1 level was reduced
significantly after being exposed to ART. In addition, UCA1 was up-regulated in
prostate cancer tissues compared to hyperplastic prostatic tissues, and a higher
UCA1 level predicted poor prognosis in PCa patients. Furthermore, reintroduction
of UCA1 into PCa cells reversed the effect of ART on apoptosis and metastatic
ability. Then we determined that the miR-184/Bcl-2 axis might be the downstream
signaling pathway of UCA1 upon ART treatment. UCA1 binds to miR-184 through its
seed sequences and may function as a sponge for miR-184.
free
free
free
