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10.18632/oncotarget.15319 http://scihub22266oqcxt.onion/10.18632/oncotarget.15319 C5392324!5392324!28212558     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (11): 18248-59 Nephropedia Template TP {{tp|p=28212558|t=2017. Ataxin-1 regulates epithelial?mesenchymal transition of cervical cancer cells |pdf=|usr=}}{{28212558}} gab.com Text Ataxin-1 regulates epithelial mesenchymal transition of cervical cancer cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28212558 #FOAvip The mutant form of the protein ataxin-1 (ATXN1) causes the neurodegenerative disease spinocerebellar ataxia type-1. Recently, ATXN1 was reported to enhance E-cadherin expression in the breast cancer cell line MCF-7, suggesting a potential association between ATXN1 and cancer development. In the present study, we discovered a novel mechanism through which ATXN1 regulates the epithelial?mesenchymal transition (EMT) of cancer cells. Hypoxia-induced upregulation of the Notch intracellular domain expression decreased ATXN1 expression via MDM2-associated ubiquitination and degradation. In cervical cancer cells, ATXN1 knockdown induced EMT by directly regulating Snail expression, leading to matrix metalloproteinase activation and the promotion of cell migration and invasion. These findings provide insights into a novel mechanism of tumorigenesis and will facilitate the development of new and more effective therapies for cancer. Twit Text FOAVip Ataxin-1 regulates epithelial mesenchymal transition of cervical cancer cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28212558 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28212558 #FOAvip English Wikipedia <ref>{{Cite pmid|28212558}}</ref> Ataxin-1 regulates epithelial?mesenchymal transition of cervical cancer cells #MMPMID28212558 Kang AR; An HT; Ko J; Kang S Oncotarget 2017[Mar]; 8 (11): 18248-59 PMID28212558show ga The mutant form of the protein ataxin-1 (ATXN1) causes the neurodegenerative disease spinocerebellar ataxia type-1. Recently, ATXN1 was reported to enhance E-cadherin expression in the breast cancer cell line MCF-7, suggesting a potential association between ATXN1 and cancer development. In the present study, we discovered a novel mechanism through which ATXN1 regulates the epithelial?mesenchymal transition (EMT) of cancer cells. Hypoxia-induced upregulation of the Notch intracellular domain expression decreased ATXN1 expression via MDM2-associated ubiquitination and degradation. In cervical cancer cells, ATXN1 knockdown induced EMT by directly regulating Snail expression, leading to matrix metalloproteinase activation and the promotion of cell migration and invasion. These findings provide insights into a novel mechanism of tumorigenesis and will facilitate the development of new and more effective therapies for cancer. äAtaxin-1 regulates epithelial?mesenchymal transition of cervical cance(epmc).pdf DeepDyve Pubget Overpricing