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10.2147/CMAR.S114526 http://scihub22266oqcxt.onion/10.2147/CMAR.S114526 C5391868!5391868!28435325     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Manag+Res 2017 ; 9 (ä): 103-13 Nephropedia Template TP {{tp|p=28435325|t=2017. The clinical development of obinutuzumab for the treatment of follicular lymphoma |pdf=|usr=}}{{28435325}} gab.com Text The clinical development of obinutuzumab for the treatment of follicular lymphoma JO: Cancer Manag Res http://www.kidney.de/pget.php?&tw=1&pmid=28435325 #FOAvip Impressive progress has been made in recent decades for advanced-stage follicular lymphoma with the availability of anti-CD20 monoclonal antibodies, initially rituximab and more recently obinutuzumab. Obinutuzumab is a unique, third-generation, fully humanized glycoengineered IgG1 type II anti-CD20 monoclonal antibody. It has been shown to have increased antitumor activity compared to rituximab in preclinical studies, including whole-blood B-cell depletion assays, xenograft models, and primate models. This has spurred on the development of obinutuzumab through Phase I/II trials as monotherapy and in combination with chemotherapeutic agents and other targeted therapies. Its efficacy compared to rituximab and in rituximab-refractory disease has led to its continued development and eventual approval for the treatment of follicular lymphoma. Here in this review, we highlight the design and development of obinutuzumab in the treatment of advanced stage grade 1?3A follicular lymphoma and its future directions. Twit Text FOAVip The clinical development of obinutuzumab for the treatment of follicular lymphoma ????Cancer Manag Res http://www.kidney.de/pget.php?&tw=1&pmid=28435325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28435325 #FOAvip English Wikipedia <ref>{{Cite pmid|28435325}}</ref> The clinical development of obinutuzumab for the treatment of follicular lymphoma #MMPMID28435325 Ma B; Ujjani C Cancer Manag Res 2017[]; 9 (ä): 103-13 PMID28435325show ga Impressive progress has been made in recent decades for advanced-stage follicular lymphoma with the availability of anti-CD20 monoclonal antibodies, initially rituximab and more recently obinutuzumab. Obinutuzumab is a unique, third-generation, fully humanized glycoengineered IgG1 type II anti-CD20 monoclonal antibody. It has been shown to have increased antitumor activity compared to rituximab in preclinical studies, including whole-blood B-cell depletion assays, xenograft models, and primate models. This has spurred on the development of obinutuzumab through Phase I/II trials as monotherapy and in combination with chemotherapeutic agents and other targeted therapies. Its efficacy compared to rituximab and in rituximab-refractory disease has led to its continued development and eventual approval for the treatment of follicular lymphoma. Here in this review, we highlight the design and development of obinutuzumab in the treatment of advanced stage grade 1?3A follicular lymphoma and its future directions. äThe clinical development of obinutuzumab for the treatment of follicul(epmc).pdf DeepDyve Pubget Overpricing