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2017 ; 11
(1
): 105
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Treatment of post-anesthesia dementia with perispinal etanercept injection and
hyperbaric oxygen therapy: a case report
#MMPMID28407792
Best S
; Pavel DG
J Med Case Rep
2017[Apr]; 11
(1
): 105
PMID28407792
show ga
BACKGROUND: We report on the first case of successful treatment for
post-anesthesia dementia with perispinal etanercept injection combined with
hyperbaric oxygen therapy. CASE PRESENTATION: Our patient was a 77-year-old
Caucasian man of Mexican ethnicity who presented to our clinic 4.5 years after a
knee replacement surgery. Immediately post-surgery, the patient began to show
dramatic cognitive, physical, and emotional impairment compared with his
presurgical state; these symptoms were still present when he arrived at our
clinic. A clinical assessment and brain single-photon emission computer
tomography were performed. Diagnoses of dementia with major cognitive deficits
and aphasia were established. A 40-session course of hyperbaric oxygen therapy
was initiated to address our patient's impairments. After the first ten
hyperbaric oxygen therapy treatments, our patient was administered 25 mg
perispinal etanercept injections approximately once weekly for 5 months. Starting
after the first perispinal etanercept injection, our patient began showing
progressive improvements. By the 5-month follow-up, his cognitive and physical
function were substantially restored. A follow-up single-photon emission computer
tomography scan showed increased perfusion in several small, localized areas.
CONCLUSIONS: In this case of dementia and major cognitive disorder post major
surgery and anesthesia, the very beneficial effect of combining hyperbaric oxygen
therapy with perispinal etanercept is outlined.