Krüppel-like factor 4 (KLF4): What we currently know #MMPMID28237823
Ghaleb AM; Yang VW
Gene 2017[May]; 611 (ä): 27-37 PMID28237823show ga
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been gaining a lot of attention, after it was shown in 2006 as one of four factors required for the induction of pluripotent stem cells (iPSCs). Here we review the current knowledge on the different functions and roles of KLF4 in various tissue and organ systems.