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10.15252/embj.201696127 http://scihub22266oqcxt.onion/10.15252/embj.201696127 C5391140!5391140!28336682     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2017 ; 36 (8): 1029-45 Nephropedia Template TP {{tp|p=28336682|t=2017. Molecular mechanism of mRNA repression in trans by a ProQ?dependent small RNA |pdf=|usr=}}{{28336682}} gab.com Text Molecular mechanism of mRNA repression in trans by a ProQ dependent small RNA JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=28336682 #FOAvip Research into post?transcriptional control of mRNAs by small noncoding RNAs (sRNAs) in the model bacteria Escherichia coli and Salmonella enterica has mainly focused on sRNAs that associate with the RNA chaperone Hfq. However, the recent discovery of the protein ProQ as a common binding partner that stabilizes a distinct large class of structured sRNAs suggests that additional RNA regulons exist in these organisms. The cellular functions and molecular mechanisms of these new ProQ?dependent sRNAs are largely unknown. Here, we report in Salmonella Typhimurium the mode?of?action of RaiZ, a ProQ?dependent sRNA that is made from the 3? end of the mRNA encoding ribosome?inactivating protein RaiA. We show that RaiZ is a base?pairing sRNA that represses in trans the mRNA of histone?like protein HU??. RaiZ forms an RNA duplex with the ribosome?binding site of hupA mRNA, facilitated by ProQ, to prevent 30S ribosome loading and protein synthesis of HU??. Similarities and differences between ProQ? and Hfq?mediated regulation will be discussed. Twit Text FOAVip Molecular mechanism of mRNA repression in trans by a ProQ dependent small RNA ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=28336682 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28336682 #FOAvip English Wikipedia <ref>{{Cite pmid|28336682}}</ref> Molecular mechanism of mRNA repression in trans by a ProQ?dependent small RNA #MMPMID28336682 Smirnov A; Wang C; Drewry LL; Vogel J EMBO J 2017[Apr]; 36 (8): 1029-45 PMID28336682show ga Research into post?transcriptional control of mRNAs by small noncoding RNAs (sRNAs) in the model bacteria Escherichia coli and Salmonella enterica has mainly focused on sRNAs that associate with the RNA chaperone Hfq. However, the recent discovery of the protein ProQ as a common binding partner that stabilizes a distinct large class of structured sRNAs suggests that additional RNA regulons exist in these organisms. The cellular functions and molecular mechanisms of these new ProQ?dependent sRNAs are largely unknown. Here, we report in Salmonella Typhimurium the mode?of?action of RaiZ, a ProQ?dependent sRNA that is made from the 3? end of the mRNA encoding ribosome?inactivating protein RaiA. We show that RaiZ is a base?pairing sRNA that represses in trans the mRNA of histone?like protein HU??. RaiZ forms an RNA duplex with the ribosome?binding site of hupA mRNA, facilitated by ProQ, to prevent 30S ribosome loading and protein synthesis of HU??. Similarities and differences between ProQ? and Hfq?mediated regulation will be discussed. äMolecular mechanism of mRNA repression in trans by a ProQ?dependent sm(epmc).pdf DeepDyve Pubget Overpricing