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10.15252/embj.201796796 http://scihub22266oqcxt.onion/10.15252/embj.201796796 C5391134!5391134!28298433     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2017 ; 36 (8): 964-6 Nephropedia Template TP {{tp|p=28298433|t=2017. Re?evaluating the foundations of lncRNA?Polycomb function |pdf=|usr=}}{{28298433}} gab.com Text Re evaluating the foundations of lncRNA Polycomb function JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=28298433 #FOAvip Many lncRNAs are thought to interact with the polycomb repressive complex 2 (PRC2) in order to regulate gene expression. A central example of this lncRNA?PRC2 paradigm in gene regulation is HOTAIR. In this issue of The EMBO Journal, a study (Portoso et al,2017) reports that while HOTAIR binds PRC2 with high affinity, the complex itself is dispensable for HOTAIR?mediated transcriptional silencing. This study raises important questions about the role of PRC2 interactions for lncRNA?mediated functions and argues for a re?evaluation of this lncRNA?PRC2 functional paradigm. Twit Text FOAVip Re evaluating the foundations of lncRNA Polycomb function ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=28298433 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28298433 #FOAvip English Wikipedia <ref>{{Cite pmid|28298433}}</ref> Re?evaluating the foundations of lncRNA?Polycomb function #MMPMID28298433 Blanco MR; Guttman M EMBO J 2017[Apr]; 36 (8): 964-6 PMID28298433show ga Many lncRNAs are thought to interact with the polycomb repressive complex 2 (PRC2) in order to regulate gene expression. A central example of this lncRNA?PRC2 paradigm in gene regulation is HOTAIR. In this issue of The EMBO Journal, a study (Portoso et al,2017) reports that while HOTAIR binds PRC2 with high affinity, the complex itself is dispensable for HOTAIR?mediated transcriptional silencing. This study raises important questions about the role of PRC2 interactions for lncRNA?mediated functions and argues for a re?evaluation of this lncRNA?PRC2 functional paradigm. äRe?evaluating the foundations of lncRNA?Polycomb function (epmc).pdf DeepDyve Pubget Overpricing